Objective
This Concerted Action was focused on research aiming at improving systemic cancer treatment based on immunotherapy. In contrast to ongoing immunotherapy approaches, emphasis was given to the combination (rather than independent use) of antibodies and effector lymphocytes.
The goal of the Concerted action was two-fold:
1. to combine the forces of the European laboratories presently involved in studies of antibody-dependant cell-mediated lysis in vitro in a coordinated effort to further define the molecular and cellular requirements for efficient cancer cell destruction.
2. to initiate clinical trials at several European cancer centers using the same protocol and reagents.
The participating laboratories were asked to share unpublished data, reagents and experimental protocols regarding the various model systems of bispecific antibody-dependent T cell-mediated cytolytic activity under study. Several in vitro systems were selected for further analysis by the participating laboratories in order to determine the various parameters influencing the efficiency of cancer cell destruction. Particular emphasis was given to the development of new procedures for the preparation of suitable bispecific antibodies as well as to the large-scale expansion of effector lymphocytes required for this form of therapy. Concomitantly, protocols for assessing the effect of this new treatment in colorectal cancer and in ovarian cancer were prepared and submitted to ethical committees of the participating cancer centers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences basic medicine immunology immunotherapy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1066 EPALINGES
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.