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Content archived on 2024-05-24

Intercellular signalling through connexin channels : a key to the understanding of cardiovascular research

Objective

The consortium project is to investigate the role of connexins in the physio(patho)logy of heart and vessels , and their involvment in the early pathogenesis of major cardiovascular disease, by an experimental approach to which aim European teams will contribute. One of the essential pathways of the intercellula signalling network which underlies the functions of all the tissues is the cell to cell coupling by means of specialized menbrane channels composed of connexins. In the diverse tissues of the cardiovascular system the cells are connected by these channels which mediate signals controlling functions as,distinct as,e.g. the coordinated contraction of myocytes or smooth muscle cells or migration and growth of endothelial cells . Dysregulation of the connexin channels interferes with the functions of the cardiovascular system : conversely chronic alteration of these functions (e.g fibrillation,hypertension) induces cells-specific changes in connexin expression elther in heart or in vascular wall.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
EU contribution
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Address
Campus de Luminy, case 907 163 Avenue de Luminy.
13288 MARSEILLE
France

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (8)

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