Objective Telomerase is an attractive target at which to aim novel cancer drugs because it maintains tumor cell immortality, and is inactive in the majority of normal human cells. In this project we will determine the precise molecular mechanisms by which telomerase is repressed in normal cells and activated in human cancer progression. Genetic inhibitors of telomerase will be developed and used to provide unequivocal evidence that anti- telomerase strategies induce replicative senescence in cancer cells, in the absence of cellular resistance machanisms. Novel reagents and procedures will be established for use in telomerase-based cancer diagnosis and in prognostic evaluations. Small molecule lead compounds (from a natural product library) that act as potent inhibitors of telomerase will be identified and characterized, as a basis for anti-telomerase drug development. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicineoncology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator BRUNEL UNIVERSITY Address Kingston lane Uxbridge United Kingdom See on map Links Website Opens in new window EU contribution € 0,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Germany EU contribution € 0,00 Address Fahnenbergplatz 79085 Freiburg (in breisgau) See on map CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 0,00 Address Campus de la universidad autonoma de madrid 28049 Madrid See on map GERMAN CANCER RESEARCH CENTER Germany EU contribution € 0,00 Address Im neuenheimer feld 280 69120 Heidelberg See on map INSTITUT SUISSE DE RECHERCHES EXPERIMENTALES SUR LE CANCER Switzerland EU contribution € 0,00 Address 155,ch. des boveresses 155 1066 Epalinges See on map MEDICAL UNIVERSITY CENTER Germany EU contribution € 0,00 Address Hugstetterstr.55 79106 Freiburg (in breisgau) See on map UNIVERSITY OF GLASGOW United Kingdom EU contribution € 0,00 Address University avenue G12 8QQ Glasgow See on map UNIVERSITY OF UMEAA Sweden EU contribution € 0,00 Address Universitetsomraadet 901 87 Umeaa See on map
