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Molecular mechanisms controlling chemokine receptor mrna stability

Objective

mRNA stability is a major checkpoint for the expression of certain chemokine receptors, affecting leukocyte recruitment in sites of infection, tumours and inflammatory diseases. The project aim is to investigate how CCR2mRNA half-life is regulated and how this influence CCR2 gene expression. mRNA stability is a major checkpoint for the expression of certain chemokine receptors, affecting leukocyte recruitment in sites of infection, tumours and inflammatory diseases. The project aim is to investigate how CCR2mRNA half-life is regulated and how this influence CCR2 gene expression.

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH
Address
Via Eritrea 62
20157 Milano
Italy