Molecular mechanisms controlling chemokine receptor mrna stability

Objective

mRNA stability is a major checkpoint for the expression of certain chemokine receptors, affecting leukocyte recruitment in sites of infection, tumours and inflammatory diseases. The project aim is to investigate how CCR2mRNA half-life is regulated and how this influence CCR2 gene expression. mRNA stability is a major checkpoint for the expression of certain chemokine receptors, affecting leukocyte recruitment in sites of infection, tumours and inflammatory diseases. The project aim is to investigate how CCR2mRNA half-life is regulated and how this influence CCR2 gene expression.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH

Address

Via Eritrea 62
20157 Milano
Italy