Objective
Type 1 von Willebrands disease (VWD) is the most common inherited bleeding disorder and results from deficiency of von Willebrand factor (VWF), a plasma protein required for normal haemostasis. Diagnosis is based on laboratory tests and a bleeding history, but can be equivocal. Precise diagnosis is important for the patient and family; misdiagnosis leads to unnecessary medical and social burdens. This project will determine molecular and clinical markers for the diagnosis and management of type 1 VWD by assessing 200 families with type 1 VWD, recruited by 12 Partners. The phenotypic basis of the diagnosis will be re-examined utilising International standards and result confirmation, new tests will be assessed and the genetic basis determined by VWF gene analysis and expression. Data on precise molecular, clinical and laboratory markers for type 1VWD will be produced.
Fields of science
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contracts
Coordinator
S10 2JF Sheffield
United Kingdom
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Participants (12)
36100 Vicenza
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B4 6NH Birmingham
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59037 Lille
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75654 Paris
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128 20 Praha 2
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59011 Lille
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2311 EZ Leiden
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205 02 Malmoe
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20122 Milano
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15006 La Coruna
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20246 Hamburg
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LE1 7RH Leicester
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