European collaboration on craniofacial anomalies

Objective

This proposal is designed to improve the management and understanding of craniofacial anomalies (CFA). Integration of previous networks established to investigate clinical care (Eurocleft.) and gene-environment interaction in early human development (ESF network) provides, for the first time in Europe, adequate clinical resources and multidisciplinary critical mass. The work includes:
1) a multicentre randomised control trial of surgery for orofacial clefting (OFC);
2) a multicentre population based case-parental triad study of the role of specific genes, gene-environment interaction and gene-gene interaction in the aetiology of OFC;
3) a chromosomal approach to the identification of candidate genes for OFC;
4) development of sensitive molecular diagnostic assay for mutations underlying monogenic CFA; and
5) an informatics resource to underpin the other work and provide a dynamic resource to disseminate findings, assist CFA researchers, and promote good practice in clinical services. The project will be integrated with, and provide leadership for, a proposed global effort in the treatment and prevention of CFA.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF MANCHESTER

Address

Higher Cambridge Street
M15 6FH Manchester
United Kingdom

Participants (18)

AZIENDA OSPEDIALIERA SAN PAOLO, MILANO

Italy

Address

Via Antonio Di Rudini N°8
20142 Milano

CLEFT PALATE FOUNDATION

Hungary

Address

Huevoesvoelgyi Ut, 35
1026 Budapest

COMENIUS UNIVERSITY

Slovakia

Address

Sasinovska, 4
81108 Bratislava

GOETEBORG UNIVERSITY

Sweden

Address

Sahlgrenska Sjukhuset
413 45 Goeteborg

MEDICAL INSTITUTE OF PLOVDIV

Bulgaria

Address

Boulevard Peschtersko Chaussee,66
4002 Plovdiv

NORTH ESTONIAN REGIONAL HOSPITAL

Estonia

Address

Suetiste Tee 19
13419 Tallinn

OSAKJDETZA SERVICIO VASCO DE SALUD

Spain

Address

Plaza De Cruces 12
489031 Barakaldo-vizcaya

SPEECH AND HEARING INSTITUTE, HELLERUP

Denmark

Address

Rygards Allee 45
2900 Hellerup

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Address

Philips Van Leijdenlaan 25
6500 HB Nijmegen

THE NATIONAL HOSPITAL UNIVERSITY OF OSLO

Norway

Address

Sognsvannsvn. 20
0027 Oslo

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN

Ireland

Address

College Green
4 Dublin

UNIVERSITA DEGLI STUDI DI FERRARA

Italy

Address

Via Luigi Borsari, 46
44100 Ferrara

UNIVERSITY MEDICAL CENTER LJUBLJANA

Slovenia

Address

Slajmerjeva, 3
1000 Ljubljana

UNIVERSITY OF ABERDEEN

United Kingdom

Address

Polwarth Building, Foresterhill
AB25 2ZD Aberdeen

UNIVERSITY OF COPENHAGEN

Denmark

Address

Noerregade 10
1017 Koebenhavn K/copenhaegen

UNIVERSITY OF DUNDEE

United Kingdom

Address

Park Place
DD1 4HR Dundee

UNIVERSITY OF HELSINKI

Finland

Address

Yliopistonkatu 4
00014 Helsinki

University of Edinburgh

United Kingdom

Address

Old College South Bridge
EH1 1HN Edinburgh