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European collaboration on craniofacial anomalies

Objective

This proposal is designed to improve the management and understanding of craniofacial anomalies (CFA). Integration of previous networks established to investigate clinical care (Eurocleft.) and gene-environment interaction in early human development (ESF network) provides, for the first time in Europe, adequate clinical resources and multidisciplinary critical mass. The work includes:
1) a multicentre randomised control trial of surgery for orofacial clefting (OFC);
2) a multicentre population based case-parental triad study of the role of specific genes, gene-environment interaction and gene-gene interaction in the aetiology of OFC;
3) a chromosomal approach to the identification of candidate genes for OFC;
4) development of sensitive molecular diagnostic assay for mutations underlying monogenic CFA; and
5) an informatics resource to underpin the other work and provide a dynamic resource to disseminate findings, assist CFA researchers, and promote good practice in clinical services. The project will be integrated with, and provide leadership for, a proposed global effort in the treatment and prevention of CFA.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF MANCHESTER
Address
Higher Cambridge Street
M15 6FH Manchester
United Kingdom

Participants (18)

AZIENDA OSPEDIALIERA SAN PAOLO, MILANO
Italy
Address
Via Antonio Di Rudini N°8
20142 Milano
CLEFT PALATE FOUNDATION
Hungary
Address
Huevoesvoelgyi Ut, 35
1026 Budapest
COMENIUS UNIVERSITY
Slovakia
Address
Sasinovska, 4
81108 Bratislava
GOETEBORG UNIVERSITY
Sweden
Address
Sahlgrenska Sjukhuset
413 45 Goeteborg
MEDICAL INSTITUTE OF PLOVDIV
Bulgaria
Address
Boulevard Peschtersko Chaussee,66
4002 Plovdiv
NORTH ESTONIAN REGIONAL HOSPITAL
Estonia
Address
Suetiste Tee 19
13419 Tallinn
OSAKJDETZA SERVICIO VASCO DE SALUD
Spain
Address
Plaza De Cruces 12
489031 Barakaldo-vizcaya
SPEECH AND HEARING INSTITUTE, HELLERUP
Denmark
Address
Rygards Allee 45
2900 Hellerup
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address
Philips Van Leijdenlaan 25
6500 HB Nijmegen
THE NATIONAL HOSPITAL UNIVERSITY OF OSLO
Norway
Address
Sognsvannsvn. 20
0027 Oslo
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland
Address
College Green
4 Dublin
UNIVERSITA DEGLI STUDI DI FERRARA
Italy
Address
Via Luigi Borsari, 46
44100 Ferrara
UNIVERSITY MEDICAL CENTER LJUBLJANA
Slovenia
Address
Slajmerjeva, 3
1000 Ljubljana
UNIVERSITY OF ABERDEEN
United Kingdom
Address
Polwarth Building, Foresterhill
AB25 2ZD Aberdeen
UNIVERSITY OF COPENHAGEN
Denmark
Address
Noerregade 10
1017 Koebenhavn K/copenhaegen
UNIVERSITY OF DUNDEE
United Kingdom
Address
Park Place
DD1 4HR Dundee
UNIVERSITY OF HELSINKI
Finland
Address
Yliopistonkatu 4
00014 Helsinki
University of Edinburgh
United Kingdom
Address
Old College South Bridge
EH1 1HN Edinburgh