Objective This proposal is designed to improve the management and understanding of craniofacial anomalies (CFA). Integration of previous networks established to investigate clinical care (Eurocleft.) and gene-environment interaction in early human development (ESF network) provides, for the first time in Europe, adequate clinical resources and multidisciplinary critical mass. The work includes:1) a multicentre randomised control trial of surgery for orofacial clefting (OFC);2) a multicentre population based case-parental triad study of the role of specific genes, gene-environment interaction and gene-gene interaction in the aetiology of OFC;3) a chromosomal approach to the identification of candidate genes for OFC;4) development of sensitive molecular diagnostic assay for mutations underlying monogenic CFA; and5) an informatics resource to underpin the other work and provide a dynamic resource to disseminate findings, assist CFA researchers, and promote good practice in clinical services. The project will be integrated with, and provide leadership for, a proposed global effort in the treatment and prevention of CFA. Fields of science medical and health sciencesclinical medicinesurgerynatural sciencesbiological sciencesgeneticsmutation Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF MANCHESTER Address Higher cambridge street M15 6FH Manchester United Kingdom See on map EU contribution € 0,00 Participants (18) Sort alphabetically Sort by EU Contribution Expand all Collapse all AZIENDA OSPEDIALIERA SAN PAOLO, MILANO Italy EU contribution € 0,00 Address Via antonio di rudini n°8 20142 Milano See on map CLEFT PALATE FOUNDATION Hungary EU contribution € 0,00 Address Huevoesvoelgyi ut, 35 1026 Budapest See on map COMENIUS UNIVERSITY Slovakia EU contribution € 0,00 Address Sasinovska, 4 81108 Bratislava See on map GOETEBORG UNIVERSITY Sweden EU contribution € 0,00 Address Sahlgrenska sjukhuset 413 45 Goeteborg See on map MEDICAL INSTITUTE OF PLOVDIV Bulgaria EU contribution € 0,00 Address Boulevard peschtersko chaussee,66 4002 Plovdiv See on map NORTH ESTONIAN REGIONAL HOSPITAL Estonia EU contribution € 0,00 Address Suetiste tee 19 13419 Tallinn See on map OSAKJDETZA SERVICIO VASCO DE SALUD Spain EU contribution € 0,00 Address Plaza de cruces 12 489031 Barakaldo-vizcaya See on map SPEECH AND HEARING INSTITUTE, HELLERUP Denmark EU contribution € 0,00 Address Rygards allee 45 2900 Hellerup See on map STICHTING KATHOLIEKE UNIVERSITEIT Netherlands EU contribution € 0,00 Address Philips van leijdenlaan 25 6500 HB Nijmegen See on map Links Website Opens in new window THE NATIONAL HOSPITAL UNIVERSITY OF OSLO Norway EU contribution € 0,00 Address Sognsvannsvn. 20 0027 Oslo See on map THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN Ireland EU contribution € 0,00 Address College green 4 Dublin See on map UNIVERSITA DEGLI STUDI DI FERRARA Italy EU contribution € 0,00 Address Via luigi borsari, 46 44100 Ferrara See on map UNIVERSITY MEDICAL CENTER LJUBLJANA Slovenia EU contribution € 0,00 Address Slajmerjeva, 3 1000 Ljubljana See on map UNIVERSITY OF ABERDEEN United Kingdom EU contribution € 0,00 Address Polwarth building, foresterhill AB25 2ZD Aberdeen See on map UNIVERSITY OF COPENHAGEN Denmark EU contribution € 0,00 Address Noerregade 10 1017 Koebenhavn k/copenhaegen See on map UNIVERSITY OF DUNDEE United Kingdom EU contribution € 0,00 Address Park place DD1 4HR Dundee See on map UNIVERSITY OF HELSINKI Finland EU contribution € 0,00 Address Yliopistonkatu 4 00014 Helsinki See on map University of Edinburgh United Kingdom EU contribution € 0,00 Address Old college south bridge EH1 1HN Edinburgh See on map
