Objective
This proposal is designed to improve the management and understanding of craniofacial anomalies (CFA). Integration of previous networks established to investigate clinical care (Eurocleft.) and gene-environment interaction in early human development (ESF network) provides, for the first time in Europe, adequate clinical resources and multidisciplinary critical mass. The work includes:
1) a multicentre randomised control trial of surgery for orofacial clefting (OFC);
2) a multicentre population based case-parental triad study of the role of specific genes, gene-environment interaction and gene-gene interaction in the aetiology of OFC;
3) a chromosomal approach to the identification of candidate genes for OFC;
4) development of sensitive molecular diagnostic assay for mutations underlying monogenic CFA; and
5) an informatics resource to underpin the other work and provide a dynamic resource to disseminate findings, assist CFA researchers, and promote good practice in clinical services. The project will be integrated with, and provide leadership for, a proposed global effort in the treatment and prevention of CFA.
Fields of science
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
M15 6FH Manchester
United Kingdom
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Participants (18)
20142 Milano
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1026 Budapest
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81108 Bratislava
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413 45 Goeteborg
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4002 Plovdiv
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13419 Tallinn
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489031 Barakaldo-vizcaya
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2900 Hellerup
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6500 HB Nijmegen
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0027 Oslo
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4 Dublin
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44100 Ferrara
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1000 Ljubljana
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AB25 2ZD Aberdeen
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1017 Koebenhavn K/copenhaegen
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DD1 4HR Dundee
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00014 Helsinki
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EH1 1HN Edinburgh
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