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Longitudinal assessment of clinical course and biomarkers in severe chronic airway disease

Objective

This aim of the proposal is to create new knowledge about severe asthma that is a major chronic debilitating disease with a great health economic impact. The proposal derives from a clinically orientated consortium of scientists who believe that substantial progress will require a detailed characterisation of the phenotype of patients. This will be accomplished in a longitudinal study of 450patients from all parts of Europe. Cohorts of severe asthmatics will be compared with mild asthmatics and patients with chronic obstructive pulmonary disease (COPD). The work packages include repeated application of modern clinical measurements and exploitation of new molecular methods to define biomarkers of chronic airway remodelling. The outcome of the work will be better diagnostic and prognostic criteria for severe airway disease and new targets for interventions.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KAROLINSKA INSTITUTE
Address
Nobels Vaeg, 13
171 77 Stockholm
Sweden

Participants (10)

GENT UNIVERSITY
Belgium
Address
Sint Pietersnieuwstraat 25
9000 Gent
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Norfolk Place, Paddington
W2 1PG London
JAGIELLONIAN UNIVERSITY
Poland
Address
Skavinska 8
31 066 Krakow
KRANKENHAUS GROSSHANSDORF GMBH
Germany
Address
Woehrendamm 80
22927 Grosshansdorf
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
Mesogion Ave. 152 Chest Hospital Sotiria
10527 Athens
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Via Trabucco 180
90146 Palermo
UNIVERSITE DE MONTPELLIER 1
France
Address
371, Av. Du Doyen Gaston Giraud
34295 Montpellier
UNIVERSITY OF CRETE
Greece
Address
Panepistimiou Street
71110 Iraklion
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Address
Tremona Road
SO16 6YD Southampton
UNIVERSITÀ DEGLI STUDI DI FERRARA
Italy
Address
Via Fossato Di Mortara, 17-19
44100 Ferrara