This aim of the proposal is to create new knowledge about severe asthma that is a major chronic debilitating disease with a great health economic impact. The proposal derives from a clinically orientated consortium of scientists who believe that substantial progress will require a detailed characterisation of the phenotype of patients. This will be accomplished in a longitudinal study of 450patients from all parts of Europe. Cohorts of severe asthmatics will be compared with mild asthmatics and patients with chronic obstructive pulmonary disease (COPD). The work packages include repeated application of modern clinical measurements and exploitation of new molecular methods to define biomarkers of chronic airway remodelling. The outcome of the work will be better diagnostic and prognostic criteria for severe airway disease and new targets for interventions.
Funding SchemeCSC - Cost-sharing contracts
W2 1PG London
31 066 Krakow
SO16 6YD Southampton