Skip to main content

Novel approaches towards the diagnosis and therapy of tumours with microsatellite instability.

Objective

A large percentage of tumours from hereditary non-polyposis colon cancer (HNPCC) patients, as well as more than 15% of sporadic colon tumours, display micro satellite instability (MSI) , which has been linked to a defect in mismatch correction (MMR) . Tumour cells with high MSI (MSI-H) differ from other cancer cells: they are largely diploid and the oncogenes and tumour suppressor genes mutated in them are frequently different from those altered in sporadic disease without MSI. We shall compare the response of normal and MSI-H cells to a series of chemotherapeutic and radiomimetic agents, as well as to ionising and non-ionising radiation. The principal aim of this program is to exploit the identified differences in cancer therapy, by devising ways of selectively killing cells with MSI. The second goal of the study is to use our findings to develop new, facile, diagnostic strategies for the identification of at-risk individuals.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIDEN UNIVERSITY
Address
72,Wassenaarseweg 72
2333 AL Leiden
Netherlands

Participants (5)

CANCER RESEARCH INSTITUTE - SLOVAK ACADEMY OF SCIENCES
Slovakia
Address
59,Vlarska 7
833 91 Bratislava
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma
PROVINCIA ITALIANA DELLA CONGREGAZIONE DEI FIGLI DELL'IMMACOLATA CONCEZIONE - ISTITUTO DERMOPATICO DELL'IMMACOLATA
Italy
Address
Via Dei Monti Di Creta 104
00167 Roma
ROSKILDE UNIVERSITY
Denmark
Address
35,Universitetsvej 1
4000 Roskilde
UNIVERSITY OF ZURICH
Switzerland
Address
August Forel-strasse 7
8008 Zurich