Magnetic resonance imaging using hyperpolarized helium gas as a tool for the diagnosis of selected respiratory diseases

Objective

Chronic Obstructive Pulmonary Diseases, including chronic bronchitis and emphysema, are of growing importance in Europe due to industrial influences, increasingly aged population and smoking habits. They can only be detected by conventional tests when already very pronounced. The project aims at validating a new non invasive method for early diagnosis, differentiation and staging of COPD: Magnetic Resonance Imaging using inhaled hyperpolarized helium 3 gas, which provides 3D anatomical images of excellent resolution, data on the dynamical function of ventilation and on airspace sizes. 9 partners from 6 countries will carry out a clinical study (150 patients, 50 volunteers), work on animal models (2 types of emphysema) and improve the methodology (production of gas, MRI techniques). The perspectives are transfer to clinics and industrial exploitation, contrast agents and drug companies, MR manufacturers).

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Funding Scheme

Coordinator

Participants (9)