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Magnetic resonance imaging using hyperpolarized helium gas as a tool for the diagnosis of selected respiratory diseases

Objective

Chronic Obstructive Pulmonary Diseases, including chronic bronchitis and emphysema, are of growing importance in Europe due to industrial influences, increasingly aged population and smoking habits. They can only be detected by conventional tests when already very pronounced. The project aims at validating a new non invasive method for early diagnosis, differentiation and staging of COPD: Magnetic Resonance Imaging using inhaled hyperpolarized helium 3 gas, which provides 3D anatomical images of excellent resolution, data on the dynamical function of ventilation and on airspace sizes. 9 partners from 6 countries will carry out a clinical study (150 patients, 50 volunteers), work on animal models (2 types of emphysema) and improve the methodology (production of gas, MRI techniques). The perspectives are transfer to clinics and industrial exploitation, contrast agents and drug companies, MR manufacturers).

Funding Scheme

CSC - Cost-sharing contracts
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Coordinator

ECOLE NORMALE SUPERIEURE
Address
24,Rue Lhomond 24
75231 Paris
France

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Lhomond 24 Laboratoire De Physique Ens
75231 Paris
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Cierm Hôpital De Bicêtre, 78 Rue Du Générale Lecle
94270 Le Kremlim Bicetre
HVIDOVRE UNIVERSITY HOSPITAL OF COPENHAGEN
Denmark
Address
30,Kettegaard Alle 30
2650 Hvidovre
JAGIELLONIAN UNIVERSITY
Poland
Address
4,Reymonta 4
30-069 Krakow
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
7,Staudingerweg 7
55099 Mainz
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Address
2,Avenida De Seneca 2, Ciudad Universitaria
28040 Madrid
UNIVERSITE CLAUDE BERNARD LYON 1
France
Address
Boulevard Du 11 Novembre 1918 43 721
69622 Villeurbanne
UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI
France
Address
4,Place Jussieu 4
75252 Paris
UNIVERSITY OF SHEFFIELD
United Kingdom
Address
Western Bank
S10 2TN Sheffield