Objective
Magnus Doverskog has been working as a Ph.D. student at the department of Biotechnology, Royal Institute of Technology, Stockholm, from January 1995 to the dissertation, May 26, 2000, under my supervision. From almost daily contacts during five years, I know Magnus Doverskog very well. Dr. Doverskog has been working on physiology and metabolism of cultured insect cells. Part of the work has been focused on the central metabolism, using NMR techniques for tracing 15N and 13C in metabolites. This work lead to a new view on the metabolism in Spodoptera frugiperda, Sf9, insect cells. Most surprisingly, it was shown that the nitrogen fixation system is present in these cells. This system was earlier thought to be present only in microorganisms and plants. Another part of Dr. Doverskog's work has dealt with amino acid metabolism, and in particular that of cystine/cysteine. All cultured insect cells had been reported to require cystine in the medium for growth. Dr. Doverskog could show that Sf9 cells were able to synthesise cysteine via the cystathionine pathway, provided that the cells were in a particular physiological state. This work lead to an investigation of the occurrence of autocrine growth factors and hormone systems in Sf9 cells. An insulin binding protein was identified in culture supernatants of Sf9 cells. This was the first report of such a protein in insect cells. A small peptide required for initiation of mitosis was also detected in the culture supernatant. In addition, the loss of productivity occurring at high cell densities in the baculovirus expression system could be related to auto-regulatory events controlling cell cycle progression. These findings will have a great impact for developing new control strategies for the baculovirus expression system. The papers included in the thesis are of high quality. Magnus Doverskog's Ph.D. work covers a broad range of subjects and methods. He has carried out his tasks with great enthusiasm and skill.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology
- natural sciences biological sciences zoology entomology
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences microbiology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.