Objective
The molecular bases of skin development, wound healing and skin diseases like psoriasis and skin cancer are still poorly understood. Keratinocytes are the major cell type of the skin. We will study the role of beta1integrins, a major group of extra cellular matrix receptors, in keratinocytes in health and disease in vivo. We generated already mice that lack beta1 integrin in keratinocytes, but not in any other tissue. These mice have severe skin defects and a complete loss of hairs. Furthermore, we will replace beta1 integrin by mutant forms of the protein in order to study the mechanisms of integrin action. These mice will be analysed in molecular and cellular aspects under normal conditions, during wound healing, in a psoriasis model and in various skin cancer models. In addition, cell lines will be established from these mice and characterised in vitro. We expect to obtain valuable information about the function, the underlying mechanism, and the target gene of beta1 integrinsin keratinocytes These data will deepen our understanding of skin physiology and path physiology and might in the future allow the development of new therapeutic schemes for skin diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
82152 MARTINSRIED
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.