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Function of b1 integrin during skin disease (B1 INTEGRIN IN SKIN)

Objective

The molecular bases of skin development, wound healing and skin diseases like psoriasis and skin cancer are still poorly understood. Keratinocytes are the major cell type of the skin. We will study the role of beta1integrins, a major group of extra cellular matrix receptors, in keratinocytes in health and disease in vivo. We generated already mice that lack beta1 integrin in keratinocytes, but not in any other tissue. These mice have severe skin defects and a complete loss of hairs. Furthermore, we will replace beta1 integrin by mutant forms of the protein in order to study the mechanisms of integrin action. These mice will be analysed in molecular and cellular aspects under normal conditions, during wound healing, in a psoriasis model and in various skin cancer models. In addition, cell lines will be established from these mice and characterised in vitro. We expect to obtain valuable information about the function, the underlying mechanism, and the target gene of beta1 integrinsin keratinocytes These data will deepen our understanding of skin physiology and path physiology and might in the future allow the development of new therapeutic schemes for skin diseases.

Call for proposal

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Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Address
Am Klopferspitz 18 A
82152 Martinsried
Germany

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Participants (5)

CANCER RESEARCH UK
United Kingdom
Address
Lincolns Inn Field 44
WC2A 3PX London

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CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIAMBIENTALES Y TECNOLOGICAS
Spain
Address
22,avenida Complutense 22
28040 Madrid

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INSTITUT CURIE
France
Address
Rue D'ulm 26
75248 Paris

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LUND UNIVERSITY
Sweden
Address
Universitetssjukhuset
221 85 Lund

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UNIVERSITY OF VIENNA
Austria
Address
Brunnerstrasse 59
1090 Wien

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