Objective Diseases as common as cancer, diabetes associated blindness and coronary arteriosclerosis, and as rare as hereditary hemorrhagic telangiecstasia (HHT), a chronic, bleeding ailment, would benefit from exogenous control of angiogenesis. Gene ablation in mice has shown that the transforming growth factor (TGF) beta signal transduction pathway is essential for normal vasculogenesis and angiogenesis while mutations in TGF beta-receptors cause HHT. Treatments of vascular disease based on interference with local ligand concentrations are not feasible because of side effects on the immune system and fibrosis. Here, we will use state-of-the-art technology to identify target genes downstream of activated receptors in vascular cells and develop cell culture and animal models for vascular disease associated with defective TGF beta signalling. Fields of science medical and health sciencesclinical medicineangiologyvascular diseasesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosismedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineoncology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF IOANNINA EU contribution No data Address 45110 IOANNINA Greece See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Belgium EU contribution No data Address Herestraat 49, Campus Gasthuisberg, Bedg. "O&H" 3000 LOUVAIN / LEUVEN See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue des Martyrs 17 38054 GRENOBLE See on map Total cost No data NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY Netherlands EU contribution No data Address Uppsalalaan 8 3584 CT UTRECHT See on map Total cost No data THE NETHERLANDS CANCER INSTITUTE / ANTONI VAN LEEUWENHOEK HOSPITAL Netherlands EU contribution No data Address 121,Plesmanlaan 121 1066 CX AMSTERDAM See on map Total cost No data UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom EU contribution No data Address Framlington Place NE2 4HH NEWCASTLE UPON TYNE See on map Total cost No data
