Objective
Human resistance to microbial infection is mediated by humoral and cellular effector systems. A major part of the humoral immune system is complement which consists of 30-35 proteins that recognize and are of utmost importance for the elimination of viruses, bacteria, fungi and parasites. Diminished complement activity causes humans to become susceptible to repetitive fulminant or severe infections. In the concerted action BMH4-CT96-1005, we analysed the contribution of two pathways of complement in detail and provided evidence that these pathways have essential roles in chronic autoimmune, inflammatory and infectious diseases. More recently a third pathway of complement activation was uncovered. There is a strong suggestion that this pathway is crucial in recognition and clearance of pathogenic microorganisms. It is the purpose of this project to delineate the relative contribution of the MBL pathway in autoimmune and infectious disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases
- natural sciences biological sciences microbiology mycology
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2333 ZA LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.