A wide range of common and lethal pathologies such as cardiovascular diseases, tumour growth and metastatic spread, are linked to the disruption of the angiogenic balance. The antiangiogenic treatments currently in clinical trials for cancer generally target a limited number of events involved in the angiogenic process. There is a pressing need to expand the number of therapeutic targets in this area. The consortium partner laboratories contribute expertise on a wide spectrum of cellular and in vivo models, providing a comprehensive representation of specific steps in neovascularization. These models will be processed by genomics analysis and promising genes will be pre-selected in vitro. The selected genes will be assessed and compared in the set of physiological and pathological models. This strategy will lead to the identification of novel critical genes and define their role in angiogenesis.
Funding SchemeCSC - Cost-sharing contracts
3000 Louvain / Leuven
61231 Bad Nauheim
79106 Freiburg (In Breisgau)