Objective
The peroxisomal disorders represent a newly recognised group of rare, inherited metabolic diseases with diverse perturbations of lipid metabolism. Although much has been learned about the enzymatic and genetic basis of these disorders, there is little information with respect to the pathogenetic mechanisms. It is our purpose to generate and analyse mouse models mimicking these diseases (MPF-2 deficiency, Refsum disease, RCDP type 1 and 2). Specific aims are:
1) to make an inventory of all metabolic changes in the different mouse models,
2) to investigate the onset and progression of pathologies in the different organs in particular in the central nervous system and in the neuromuscular system
3) to study the molecular mechanisms linking metabolic alterations with organ dysfunction by in vivo and in vitro approaches
4) to use these mouse models to evaluate diets and treatments.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences health sciences nutrition
- medical and health sciences basic medicine pathology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3000 LOUVAIN / LEUVEN
Belgium
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