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The cellular fuel gauge amp-activated protein kinase: a key player in type 2 diabetes and the metabolic syndrome?

Objective

Type 2 diabetes and the related metabolic syndrome (a cluster of abnormalities including insulin resistance, obesity, hyperlipidaemia, and hypertension) are increasing in prevalence, due to an ageing population and to lifestyle factors, notably diet and exercise. Diabetes causes debilitating long-term complications, while the components of the metabolic syndrome are key risk factors for cardiovascular disease. The AMP-activated protein kinase (AMPK) system monitors the energy status of cells, is activated by exercise or low glucose, and acts as a "metabolic master switch" turning catabolic and anabolic pathways on and off. The same pathways are altered in metabolic syndrome, suggesting that AMPK might be playing a role in its development. Our proposal brings together a multidisciplinary group of leading European researchers, and should provide the knowledge base and tools for development of new therapeutic regimes.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF DUNDEE
Address
Nethergate
DD1 4HN Dundee
United Kingdom

Participants (6)

CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY
Belgium
Address
Avenue Hippocrate 75, Icp 75.50
Bruxelles
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Calle Serrano 117
Madrid
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Du Cane Road, Hammersmith Hospital
W12 0NN London
NOVO-NORDISK A/S
Denmark
Address
Novo Allee, Building 6A
2880 Bagsvaerd
UNIVERSITY OF COPENHAGEN
Denmark
Address
Universitetsparken 13
2100 Koepenhagen