Objective ER is a classic receptor kinase, which, upon ligand binding, transduces a kinase dependent signal allowing the migration of RET-expressing cells towards ligand source. However recent findings show that RET expression induces apoptosis in the absence of ligand. The dependence receptor notion is based on similar observations that the effects of a number of receptors functioning in both nervous system development and tumorigenesis cannot be explained imply by a positive effect of signal transduction induced by ligand binding. Receptors such as neurotrophin receptor p75NTR, the androgen receptor (AR), DCC (Deleted in Colorectal Cancer), and now RET show two distinct forms of signal transduction depending on ligand availability. In the presence of their ligands they transduce a signal for either proliferation or differentiation and in their absence for apoptosis. This project aims at studying the biological role of RET in model systems and in humans. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesclinical medicineoncologyprostate cancermedical and health sciencesclinical medicineoncologycolorectal cancer Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator ISTITUTO GIANNINA GASLINI Address Largo gerolamo gaslini 5 16148 Genova Italy See on map EU contribution € 0,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Germany EU contribution € 0,00 Address Schaenzlestrasse 1 79104 Freiburg See on map CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution € 0,00 Address Boulevard du 11 novembre 1918, 43 69622 Villeurbanne See on map INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 0,00 Address Rue de sèvres 149 75743 Paris See on map ISTITUTO EUROPEO DI ONCOLOGIA SRL Italy EU contribution € 0,00 Address Via ripamonti 435 20141 Milano See on map ITALIAN AGENCY FOR NEW TECHNOLOGY, ENERGY AND THE ENVIRONMENT Italy EU contribution € 0,00 Address Via anguillarese 301 00060 Capena See on map UNIVERSITA DEGLI STUDI DI PISA Italy EU contribution € 0,00 Address Via a. volta 6 56126 Pisa See on map UNIVERSITE CLAUDE BERNARD LYON 1 France EU contribution € 0,00 Address 43,boulevard du 11 novembre 1918, 43 69622 Villeurbanne See on map
