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Ret as dependence receptor involved in apoptosis, neurogenesis and tumorigenesis

Objective

ER is a classic receptor kinase, which, upon ligand binding, transduces a kinase dependent signal allowing the migration of RET-expressing cells towards ligand source. However recent findings show that RET expression induces apoptosis in the absence of ligand. The dependence receptor notion is based on similar observations that the effects of a number of receptors functioning in both nervous system development and tumorigenesis cannot be explained imply by a positive effect of signal transduction induced by ligand binding. Receptors such as neurotrophin receptor p75NTR, the androgen receptor (AR), DCC (Deleted in Colorectal Cancer), and now RET show two distinct forms of signal transduction depending on ligand availability. In the presence of their ligands they transduce a signal for either proliferation or differentiation and in their absence for apoptosis. This project aims at studying the biological role of RET in model systems and in humans.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ISTITUTO GIANNINA GASLINI
Address
Largo Gerolamo Gaslini 5
16148 Genova
Italy

Participants (7)

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
Address
Schaenzlestrasse 1
79104 Freiburg
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Boulevard Du 11 Novembre 1918, 43
69622 Villeurbanne
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Sèvres 149
75743 Paris
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
Address
Via Ripamonti 435
20141 Milano
ITALIAN AGENCY FOR NEW TECHNOLOGY, ENERGY AND THE ENVIRONMENT
Italy
Address
Via Anguillarese 301
00060 Capena
UNIVERSITA DEGLI STUDI DI PISA
Italy
Address
Via A. Volta 6
56126 Pisa
UNIVERSITE CLAUDE BERNARD LYON 1
France
Address
43,Boulevard Du 11 Novembre 1918, 43
69622 Villeurbanne