Skip to main content

Targeting chromatin in cancer: histone deacetylases and differentiation therapy of acute myeloid leukemias (CHROMATIN AND CANCER)

Objective

Acetylation/deacetylation by histone acetylases (HAT) and deacetylases (HDAC) regulates gene transcription and specific functions, such as tumour suppression by p53. Abnormalities of HAT or HDAC are frequently found in tumours. Targeting of HDAC by small compounds is effective in the differentiation treatment of a small subset of leukaemia. We aim to determine whether HDACs are suitable general targets for cancer drug discovery. We will characterize the mechanisms of activities of HDAC/HAT in normal and cancer cells, and screen tumours with a panel of HDAC inhibitors. Our experimental approaches range from biochemistry, to molecular biology, to post-genomics (proteomics and nanotechnology), and include the functional validation of compounds and demonstrated mechanisms in animal model systems and tumour samples. Final objective is the design of differentiation treatment protocols for leukaemia and myelodysplastic syndromes.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ISTITUTO EUROPEO DI ONCOLOGIA SRL
Address
Via Ripamonti 435
20141 Milano
Italy

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
GEORG-SPEYER-HAUS - CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT
Germany
Address
Paul-ehrlich-strasse 42-44
60596 Frankfurt Am-main
HOSPITAL UNIVERSITARIO DE LA FE SEVASA
Spain
Address
Avenida De Campanar 21
46009 Valencia
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 28
75724 Paris
SECONDA UNIVERSITA DEGLI STUDI DI NAPOLI
Italy
Address
Piazza S. Andrea Delle Dame 2
80138 Napoli
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address
Geert Grootepelin 26 Zuid
6500 HB Nijmegen
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Via A.scarpa 14
00191 Roma
University of Cambridge
United Kingdom
Address
Tennis Court Road
CB2 1QR Cambridge