Objective Acetylation/deacetylation by histone acetylases (HAT) and deacetylases (HDAC) regulates gene transcription and specific functions, such as tumour suppression by p53. Abnormalities of HAT or HDAC are frequently found in tumours. Targeting of HDAC by small compounds is effective in the differentiation treatment of a small subset of leukaemia. We aim to determine whether HDACs are suitable general targets for cancer drug discovery. We will characterize the mechanisms of activities of HDAC/HAT in normal and cancer cells, and screen tumours with a panel of HDAC inhibitors. Our experimental approaches range from biochemistry, to molecular biology, to post-genomics (proteomics and nanotechnology), and include the functional validation of compounds and demonstrated mechanisms in animal model systems and tumour samples. Final objective is the design of differentiation treatment protocols for leukaemia and myelodysplastic syndromes. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsengineering and technologynanotechnologymedical and health sciencesclinical medicineoncologyleukemianatural sciencesbiological sciencesmolecular biology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator ISTITUTO EUROPEO DI ONCOLOGIA SRL EU contribution No data Address Via Ripamonti 435 20141 MILANO Italy See on map Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue Laurent Fries 1 67404 ILLKIRCH GRAFFENSTADEN See on map Total cost No data GEORG-SPEYER-HAUS - CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT Germany EU contribution No data Address Paul-Ehrlich-Strasse 42-44 60596 FRANKFURT AM-MAIN See on map Total cost No data HOSPITAL UNIVERSITARIO DE LA FE SEVASA Spain EU contribution No data Address Avenida de Campanar 21 46009 VALENCIA See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue Laurent Fries 1 67404 ILLKIRCH GRAFFENSTADEN See on map Total cost No data INSTITUT PASTEUR France EU contribution No data Address Rue du Docteur Roux 28 75724 Paris See on map Total cost No data SECONDA UNIVERSITA DEGLI STUDI DI NAPOLI Italy EU contribution No data Address Piazza S. Andrea delle dame 2 80138 NAPOLI See on map Total cost No data STICHTING KATHOLIEKE UNIVERSITEIT Netherlands EU contribution No data Address Geert Grootepelin 26 zuid 6500 HB NIJMEGEN See on map Total cost No data UNIVERSITY OF ROME "LA SAPIENZA" Italy EU contribution No data Address Via A.Scarpa 14 00191 ROMA See on map Total cost No data University of Cambridge United Kingdom EU contribution No data Address Tennis Court Road CB2 1QR Cambridge See on map Total cost No data