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Alleviation of chronic inflammatory diseases - targeting of phosphoinositide 3-kinases (ACID)

Objective

Chronic inflammatory diseases cause substantial individual suffering and cost to society. Most diseases lack cures, and available long-term medication relieves symptoms only at the expense of severe side effects. Insight into signals in leukocyte traffic pave the way for novel strategies to treat of chronic inflammation. Chemokine receptors relay their signal through phosphoinositide 3-kinase (PI3K) . We have recently demonstrated that the G protein-coupled PI3Kg acts as an essential regulator of leukocyte migration and adhesion, both key features of cell activation during the inflammatory process. This project is to validate PI3Kg and PI3Kd - both highly expressed in cells of haematopoietic origin - as drug targets. PI3K null mice shall be tested in chronic inflammation models. Studies of PI3K signalling in white blood cells shall elucidate the role of PI3Ks in chronic inflammation. Finally, selective PI3K inhibitors shall be produced.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KLINIKUM DER FRIEDRICH-SCHILLER-UNIVERSITAET JENA
Address
Drackendorfer Strasse 1
07740 Jena
Germany

Participants (5)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Campus De La Universidad Autonoma De Madrid
28049 Madrid
LUDWIG INSTITUTE FOR CANCER RESEARCH
United Kingdom
Address
Riding House Street 91
W1W 7BS London
SERONO INTERNATIONAL S.A.
Switzerland
Address
Chemin Des Aulx 14
1228 Plan-les-ouates
UNIVERSITY OF FRIBOURG
Switzerland
Address
Rue Du Musee 5
1700 Fribourg
UNIVERSITY OF TORINO
Italy
Address
Via Santena 19
10126 Torino (Turin)