Differential genetic makeup and mrna expression profiles of sardinian alcohol preferring rat line by use of dna microarrays genechip technology.

Objective

Technology development is an essential part of modern genetic research. With the existing techniques it is possible to test only one single gene each time; as a consequence, a lot of time it is spent by the scientists on the gene expression experiments. Using the Gene-Chip technology we can test at the same time on a single slide the expression of all genes known in specific tissues or mutations in patient samples quickly in parallel. It will be used "GeneChip" on two particular families of laboratory rats, the Sardinian alcohol -preferring and the Sardinian alcohol-non-preferring. They constitute a suitable animal model for searching for gene expression patterns in the identification of effective molecules for alcoholism. Neuroscienze and AAT decided to carry out this project together because a remarkable added value can come out from this partnership (combination between knowledge and technology). This would prove to be the most cost-effective way to reach the final goal of knowledge on the function of all genes . The expected results will be exploit mainly by Neuroscienze with the pharmaceutics companies and by AAT with the biotechnology enterprises.

Programme(s)

FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Funding Scheme

EAW - Exploratory awards

Coordinator

CENTRO CONSORTILE RICERCHE NEUROPSICOFARMACOLOGICHE A.R.L.

Address

Via Palabanda 9
09125 Cagliari
Italy

Participants (1)

EPPENDORF ARRAY TECHNOLOGIES S.A.

Belgium