Objective
Despite a vast amount of investigation on the pathophysiology of Down syndrome (DS) (T21), the molecular, biochemical and cellular bases of this common cause of mental retardation (over 500.000 cases in Europe) are still unknown. The sequence of human chromosome 21, cells and tissues from individuals with partial or regular T21 (molecularly and phenotypically described) and functional approaches (expression profiling, yeast double hybrid, transcriptome and proteome) should permit: a/to identify the molecules that are involved in DS brain alterations and the modifier factors responsible of the phenotypic variability; b/to modelize the dosage effects of the DS transcriptome in mouse; and c/ to develop protective and therapeutic strategies for the treatment of the chronic neurological alterations of DS patients. This understanding of DS should also provide basic knowledge about the causes of common clinical neurological alterations in humans.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesbasic medicinephysiologypathophysiology
- natural sciencesbiological sciencesgeneticschromosomes
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
75251 PARIS
France