Objective ACE inhibitors are renoprotective in adults with chronic renal failure (CRF), but of unproven usefulness in children. In a randomised trial in 350 CRF children we will address if ACE inhibition is efficacious in slowing CRF progression in acquired and congenital nephropathies, if progression can be additionally influenced by intensified antihypertensive treatment achieving low-normal blood pressure, and which factors determine CRF progression and/or its susceptibility to ACE inhibition. Potential effects of renin-angiotensin system and PAI-l gene polymorphisms, mutations in genes defining glomerular structure or causing renal hypo/dysplasia, renal endothelnr-l turnover, plasma homocysteine and apolipoprotein phenotypes will be assessed. The cardiovascular consequences of childhood-onset CRF and renoprotective pharmacotherapy will be addressed by carotid ultrasound, echocardiography and 24-hour blood pressure monitoring. Fields of science natural sciencesbiological sciencesgeneticsmutationnatural sciencesphysical sciencesacousticsultrasound Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITAETSKLINIKUM HEIDELBERG Address Im neuenheimer feld 150 69115 Heidelberg Germany See on map EU contribution € 0,00 Participants (27) Sort alphabetically Sort by EU Contribution Expand all Collapse all AZIENDA OSPEDALIERA AUTONOMA - SANT'ANNA - O.I.R.M. TORINO Italy EU contribution € 0,00 Address Piazza polonia, 94 10126 Torino (turin) See on map AZIENDA OSPEDALIERA DI PADOVA Italy EU contribution € 0,00 Address Via giustiniani 3 35128 Padova See on map AZIENDA OSPEDALIERA ISTITUTI CLINICI DI PERFEZIONAMENTO Italy EU contribution € 0,00 Address Via della commenda 9 20122 Milano See on map CERRAHPASA MEDICAL FACULTY Türkiye EU contribution € 0,00 Address Kocamustafapasa 34303 Istanbul See on map CHILDREN'S MEMORIAL HEALTH INSTITUTE Poland EU contribution € 0,00 Address Aleja dzieci polskich 20 04 736 Warszawa See on map HACETTEPE UNIVERSITY Türkiye EU contribution € 0,00 Address Sihhiye 06100 Ankara See on map HANNOVER MEDICAL SCHOOL Germany EU contribution € 0,00 Address Carl-neuberg-strasse 1 30625 Hannover See on map HOPITAUX UNIVERSITAIRES DE STRASBOURG France EU contribution € 0,00 Address Avenue moliere 67098 Strasbourg See on map HOSPITAL SAO JOAO Portugal EU contribution € 0,00 Address Alameda prof. hernani monteiro 4202-451 Porto See on map HUDDINGE UNIVERSITY HOSPITAL Sweden EU contribution € 0,00 Address 141 86 Huddinge See on map HUMBOLDT-UNIVERSITAET BERLIN Germany EU contribution € 0,00 Address Schumannstrasse 20/21 10117 Berlin See on map INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 0,00 Address Rue de sevres 149-161 75743 Paris See on map ISTANBUL MEDICAL FACULTY Türkiye EU contribution € 0,00 Address Capa 34390 Istanbul See on map ISTITUTO GIANNINA GASLINI Italy EU contribution € 0,00 Address Largo gerlamo gaslini 5 16148 Genova See on map JOHANNES GUTENBERG UNIVERSITAET MAINZ Germany EU contribution € 0,00 Address Langenbeckstrasse 1 55101 Mainz See on map PAEDIATRIC HOSPITAL BAMBINO GESU Italy EU contribution € 0,00 Address 4,piazza sant' onofrio 4 00165 Roma See on map PHILIPPS UNIVERSITY MARBURG Germany EU contribution € 0,00 Address Deutschhausstrasse 12 35043 Marburg See on map POMERANIAN MEDICAL ACADEMY Poland EU contribution € 0,00 Address Unii lubelskiej 1 70 954 Szczecin See on map SEMMELWEIS UNIVERSITY OF MEDICINE Hungary EU contribution € 0,00 Address Bokay janos u. 53 1083 Budapest See on map STAEDLISCHES KLINIKUM ST. GEORG Germany EU contribution € 0,00 Address Delitzscher strasse 141 04129 Leipzig See on map UNIVERSITAETSKLINIKUM ESSEN, ANSTALT DES OFFENTLICHEN RECHTS Germany EU contribution € 0,00 Address Hufelandstrasse 55 45122 Essen See on map UNIVERSITY CHILDREN'S HOSPITAL Switzerland EU contribution € 0,00 Address Steinwiesstr. 75 8032 Zurich See on map UNIVERSITY HOSPITAL HAMBURG-EPPENDORF Germany EU contribution € 0,00 Address C/o university children's hospital, martinistrasse 20246 Hamburg See on map UNIVERSITY HOSPITAL MOTOL Czechia EU contribution € 0,00 Address V uvalu 84 150 06 Praha 5 See on map UNIVERSITY OF BELGRADE EU contribution € 0,00 Address Tirsova 10 11000 Belgrade See on map UNIVERSITY OF CUKUROVA Türkiye EU contribution € 0,00 Address Balcali 01330 Adana See on map UNIVERSITY OF EGE Türkiye EU contribution € 0,00 Address Ege universitesi kampusu 35040 Bornova See on map
