Molecular mechanisms of disease progression and renoprotective pharmacotherapy in children with chronic renal failure

Project Information

ESCAPE_TRIAL

Grant agreement ID: QLG1-CT-2002-00908

Project closed

Start date 1 September 2002

End date 31 May 2006

Funded under

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Total cost € 1 906 187,00

EU contribution € 1 604 329,00

Coordinated by

UNIVERSITAETSKLINIKUM HEIDELBERG
Germany

Objective

ACE inhibitors are renoprotective in adults with chronic renal failure (CRF), but of unproven usefulness in children. In a randomised trial in 350 CRF children we will address if ACE inhibition is efficacious in slowing CRF progression in acquired and congenital nephropathies, if progression can be additionally influenced by intensified antihypertensive treatment achieving low-normal blood pressure, and which factors determine CRF progression and/or its susceptibility to ACE inhibition. Potential effects of renin-angiotensin system and PAI-l gene polymorphisms, mutations in genes defining glomerular structure or causing renal hypo/dysplasia, renal endothelnr-l turnover, plasma homocysteine and apolipoprotein phenotypes will be assessed. The cardiovascular consequences of childhood-onset CRF and renoprotective pharmacotherapy will be addressed by carotid ultrasound, echocardiography and 24-hour blood pressure monitoring.

Fields of science

• natural sciences › biological sciences › genetics › mutation
• natural sciences › physical sciences › acoustics › ultrasound

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITAETSKLINIKUM HEIDELBERG

• EU contribution: No data
• Address: Im Neuenheimer Feld 150 ; 69115 HEIDELBERG ; Germany
• Total cost: No data

Participants (27)

AZIENDA OSPEDALIERA AUTONOMA - SANT'ANNA - O.I.R.M. TORINO

Italy

• EU contribution: No data
• Address: Piazza Polonia, 94 ; 10126 TORINO (TURIN)
• Total cost: No data

AZIENDA OSPEDALIERA DI PADOVA

Italy

• EU contribution: No data
• Address: via Giustiniani 3 ; 35128 PADOVA
• Total cost: No data

AZIENDA OSPEDALIERA ISTITUTI CLINICI DI PERFEZIONAMENTO

Italy

• EU contribution: No data
• Address: Via della Commenda 9 ; 20122 MILANO
• Total cost: No data

CERRAHPASA MEDICAL FACULTY

Türkiye

• EU contribution: No data
• Address: Kocamustafapasa ; 34303 ISTANBUL
• Total cost: No data

CHILDREN'S MEMORIAL HEALTH INSTITUTE

Poland

• EU contribution: No data
• Address: Aleja Dzieci Polskich 20 ; 04 736 WARSZAWA
• Total cost: No data

HACETTEPE UNIVERSITY

Türkiye

• EU contribution: No data
• Address: Sihhiye ; 06100 ANKARA
• Total cost: No data

HANNOVER MEDICAL SCHOOL

Germany

• EU contribution: No data
• Address: Carl-Neuberg-Strasse 1 ; 30625 HANNOVER
• Total cost: No data

HOPITAUX UNIVERSITAIRES DE STRASBOURG

France

• EU contribution: No data
• Address: Avenue Moliere ; 67098 STRASBOURG
• Total cost: No data

HOSPITAL SAO JOAO

Portugal

• EU contribution: No data
• Address: Alameda Prof. Hernani Monteiro ; 4202-451 PORTO
• Total cost: No data

HUDDINGE UNIVERSITY HOSPITAL

Sweden

• EU contribution: No data
• Address: 141 86 HUDDINGE
• Total cost: No data

HUMBOLDT-UNIVERSITAET BERLIN

Germany

• EU contribution: No data
• Address: Schumannstrasse 20/21 ; 10117 BERLIN
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: No data
• Address: Rue de Sevres 149-161 ; 75743 PARIS
• Total cost: No data

ISTANBUL MEDICAL FACULTY

Türkiye

• EU contribution: No data
• Address: Capa ; 34390 ISTANBUL
• Total cost: No data

ISTITUTO GIANNINA GASLINI

Italy

• EU contribution: No data
• Address: Largo Gerlamo Gaslini 5 ; 16148 GENOVA
• Total cost: No data

JOHANNES GUTENBERG UNIVERSITAET MAINZ

Germany

• EU contribution: No data
• Address: Langenbeckstrasse 1 ; 55101 MAINZ
• Total cost: No data

PAEDIATRIC HOSPITAL BAMBINO GESU

Italy

• EU contribution: No data
• Address: 4,Piazza Sant' Onofrio 4 ; 00165 Roma
• Total cost: No data

PHILIPPS UNIVERSITY MARBURG

Germany

• EU contribution: No data
• Address: Deutschhausstrasse 12 ; 35043 MARBURG
• Total cost: No data

POMERANIAN MEDICAL ACADEMY

Poland

• EU contribution: No data
• Address: unii Lubelskiej 1 ; 70 954 SZCZECIN
• Total cost: No data

SEMMELWEIS UNIVERSITY OF MEDICINE

Hungary

• EU contribution: No data
• Address: Bokay Janos u. 53 ; 1083 BUDAPEST
• Total cost: No data

STAEDLISCHES KLINIKUM ST. GEORG

Germany

• EU contribution: No data
• Address: Delitzscher Strasse 141 ; 04129 LEIPZIG
• Total cost: No data

UNIVERSITAETSKLINIKUM ESSEN, ANSTALT DES OFFENTLICHEN RECHTS

Germany

• EU contribution: No data
• Address: Hufelandstrasse 55 ; 45122 ESSEN
• Total cost: No data

UNIVERSITY CHILDREN'S HOSPITAL

Switzerland

• EU contribution: No data
• Address: Steinwiesstr. 75 ; 8032 ZURICH
• Total cost: No data

UNIVERSITY HOSPITAL HAMBURG-EPPENDORF

Germany

• EU contribution: No data
• Address: c/o University Children's Hospital, Martinistrasse ; 20246 HAMBURG
• Total cost: No data

UNIVERSITY HOSPITAL MOTOL

Czechia

• EU contribution: No data
• Address: V Uvalu 84 ; 150 06 PRAHA 5
• Total cost: No data

UNIVERSITY OF BELGRADE

• EU contribution: No data
• Address: Tirsova 10 ; 11000 BELGRADE
• Total cost: No data

UNIVERSITY OF CUKUROVA

Türkiye

• EU contribution: No data
• Address: Balcali ; 01330 ADANA
• Total cost: No data

UNIVERSITY OF EGE

Türkiye

• EU contribution: No data
• Address: Ege Universitesi Kampusu ; 35040 BORNOVA
• Total cost: No data