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Clinical features associated with tropheryma whipplei infection in an european setting - pathogenesis, diagnosis and treatment of whipple's disease

Objective

Whipple's disease (WD) is a rare, multifactorial disease, in which the bacterium Tropheryma whipplei causes infections in predisposed hosts. We plan to set up the first multidisciplinary consortium to improve our understanding of the interaction of host, agent and environment in this disorder. This includes a coordinated collection of different tissues from WD patients and controls, studies of host factors (characterizing the underlying immunogenetic defect) and of environmental factors (occurrence of T. whipplei). In order to improve diagnosis, microbiologic characterization of the agent will include studies of growth conditions (allowing antibiotic susceptibility testing) and sequencing of the bacillus. Prospective therapy studies aim to improve the current antibiotic therapy and to test beneficial effects of new supportive treatments. This should lead to a significant improvement of the patients' disease burden.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

SAARLAND UNIVERSITY
Address
Kirrberger Str.
66421 Homburg
Germany

Participants (8)

CHARITE UNIVERSITAETMEDIZIN BERLIN - CAMPUS BENJAMIN FRANKLIN
Germany
Address
Hindenburgdamm, 30
12200 Berlin
DRK KRANKENHAUS NEUWIED
Germany
Address
Markstr. 104
56564 Neuwied
EUROPEAN RESEARCH AND PROJECT OFFICE
Germany
Address
Science Park Saar, Stuhlsatzenhausweg 69
66123 Saarbruecken
IRCCS POLICLINICO SAN MATTEO - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Address
Piazzale Camillo Golgi 19
27100 Pavia
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Minderbroedersstraat 12
3000 Louvain / Leuven
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Ihnestrasse 73
14195 Berlin
MEDICAL UNIVERSITY OF VIENNA
Austria
Address
Waehringer Guertel, 18-20
1090 Wien
UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II
France
Address
Boulevard Jean Moulin 27
13385 Marseille