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Content archived on 2024-05-27

Diagnostic approaches to chimerism testing after allogenic stem cell transplantation for early detection of graft rejection and relapse: technical development, standardization, and european coordinated clinical implementation (EUROCHIMERISM

Objective

Transplantation of haematopoietic stem cells from related or unrelated donors is becoming an increasingly important approach to treatment of different malignant and non-malignant disorders. There is thus growing demand for clinical diagnostic methodologies permitting the surveillance of donor- and recipient-derived hemopoiesis (=chimerism) during the post transplant period. The techniques currently used are very heterogeneous, rendering uniform evaluation and comparison of diagnostic results between centres difficult. International efforts aimed at the development of standardized methods are therefore urgently needed. We intend to establish a diagnostic standard for the monitoring of chimerism after allogeneic stem cell transplantation (SCT). Leading laboratories in this field from 10 European countries will collaborate to develop and standardize a molecular diagnostic assay meeting stringent quality criteria that could be adopted at all diagnostic centres involved. Implementation of international consensus criteria for appropriate investigation of chimerism after allogeneic SCT will provide a basis for optimum diagnostic support for clinical decision-making.

Fields of science (EuroSciVoc)

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Topic(s)

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Funding Scheme

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CON - Coordination of research actions

Coordinator

CHILDRENS CANCER RESEARCH INSTITUTE
EU contribution
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Address
Kinderspitalgasse 6
1090 WIEN
Austria

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Total cost

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Participants (10)

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