Objective
A substantial proportion of patients with non-insulin requiring diabetes progress to insulin therapy. Many cases, despite being adults, have immune and genetic features of autoimmune type 1 diabetes. Such adult autoimmune non-insulin requiring diabetic patients probably comprise the majority of cases of autoimmune diabetes in Europe and their condition is described as latent autoimmune diabetes of adults (LADA). This proposal aims:
1 ) to define the prevalence of LADA across Europe by testing non-insulin requiring diabetes patients for antibodies to glutamic acid decarboxylase;
2) to characterise LADA in terms of genetic, immune and metabolic features, and
3) to prevent or delay progression to insulin dependence in LADA using a immune modulation therapy with a heat shock protein altered peptide (Diapep 277). The double-blind randomised prevention trial will determine in a group of recent onset LADA patients whether therapy with Diapep277 can modify the natural history of the disease. Such therapy, if successful in reducing progression to insulin dependence, could be used to prevent autoimmune type 1 diabetes in children.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- humanities history and archaeology history
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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