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Cancer anatomy of chromosome 11q23: identification, mutation, expression and functional analyses of tumor susceptibility genes

Objective

This projects seeks to identify and define the role of genes located within two non- overlapping regions (LOH regions 1 and 2) at chromosome 11q23 that are frequently deleted in various types of human neoplasme.The project proposes to determine the trans- criptional map of these regions by mapping ESTs and sequencing the entire LOH region 2. It also proposes to characterize resident genes for their expression pattern and presence of mutations tumours samples. For genes involved in tumorigenesis by mutation/expression studies functional studies involving suppression of tumorigenicity assays, animal models and identification of interacting proteins will be conducted. An internal service, we will develop a tumour databank that should serve the scientific needs of the consortium. We expect to open the way to the development of new molecular diagnostics and to the identification of new biological targets for therapeutic intervention.

Coordinator

UNIVERSITÀ DEGLI STUDI DI FERRARA
Address
Via Luigi Borsari, 46
44100 Ferrara
Italy

Participants (2)

UNIVERSITY OF SOUTHAMPTON
United Kingdom
Address
C/o Duthie Building, Southampton General Hospital
SO16 6YD Southampton
University of Ulm
Germany
Address
Albert-einstein-allee 11
89070 Ulm