Obiettivo
This projects seeks to identify and define the role of genes located within two non- overlapping regions (LOH regions 1 and 2) at chromosome 11q23 that are frequently deleted in various types of human neoplasme.The project proposes to determine the trans- criptional map of these regions by mapping ESTs and sequencing the entire LOH region 2. It also proposes to characterize resident genes for their expression pattern and presence of mutations tumours samples. For genes involved in tumorigenesis by mutation/expression studies functional studies involving suppression of tumorigenicity assays, animal models and identification of interacting proteins will be conducted. An internal service, we will develop a tumour databank that should serve the scientific needs of the consortium. We expect to open the way to the development of new molecular diagnostics and to the identification of new biological targets for therapeutic intervention.
Campo scientifico
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesgeneticsmutation
- medical and health sciencesclinical medicineoncology
- natural sciencesmathematicspure mathematicsmathematical analysisfunctional analysis
- natural sciencesbiological sciencesgeneticschromosomes
Invito a presentare proposte
Data not availableMeccanismo di finanziamento
CSC - Cost-sharing contractsCoordinatore
44100 FERRARA
Italia