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From gene regulation to gene function: regulatory networks in the model gram-positive bacterium bacillus subtilis

Objective

As unicellular organisms, bacteria must match their metabolic activity to the requirements of the environment. This is achieved by regulatory networks that respond to intra-and extra-cellular signals by modulating gene expression. This proposal aims to generate new data on the regulation of gene expression in bacillus subtilis using state-of-the-art technologies for analysing the proteome and transcriptome. The information will be constructed, in silico, into a model of the global regulatory networks that result from interactions between individual regulatory circuits. It will make full use of bioinformatical and physical resources generated by the european bacillus community during previous sequencing and functional analysis projects. The data will provide new strategies for the identification of gene function and will provide clues to general stress mechanisms induced in pathogenic bacteria in response to infection. A major outcome will be an innovative transcriptional database, subscript, that is inter-linked to existing genomic, proteomic and phenotypic databases, to provide one of the most complete descriptions of living organism.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE
Address
Framlington Place
NE2 4HH Newcastle - Upon Tyne
United Kingdom

Participants (7)

INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 25
75724 Paris
Institut National de la Recherche Agronomique (INRA)
France
Address
147 Rue De L'université
75341 Paris
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
Mannerheimintie 166
00300 Helsinki
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland
Address
Trinity College
2 Dublin
UNIVERSITAET BAYREUTH
Germany
Address
Universitaetsstrasse 30
95447 Bayreuth
UNIVERSITY OF GREIFSWALD
Germany
Address
F.-l.-jahnstrasse 15
17487 Greifswald
UNIVERSITY OF GRONINGEN
Netherlands
Address
30,Kerklaan 30
9750 AA Haren Gn