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Development of novel gene expression and genome modification strategies


Gene transfer protocols used for bio molecule productions and therapeutic strategies suffer from lack of control of the fate of the foreign DNA within the host genome. The efficient expression of the transferred DNA relies on the site of its integration, on the presence of cis DNA regulatory elements and on nuclear proteins which participate in the formation of the chromatin at the transgeniclocus. This proposal aims at studying all these contributing factors in order to develop methods which can target the foreign DNA at preselected, precharacterised sites in the genome and guarantee stable and/or regulatable expression of the transferred genes, without interrupting or activating endogenous neighbouring gene loci.

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Régime de financement

CSC - Cost-sharing contracts


MRC National Institute for Medical Research
Contribution de l’UE
Aucune donnée
The Ridgeway Mill Hil
NW7 1AA London

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Participants (7)