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Integrated system to manage the enormous complexity of the genome and proteome of the specific immune response: imgt, the international immunogenetics database.

Objective

Europe has taken a lead in the development of IGMT, an high-quality integrated ImMunoGeneTics database, unique in the world, specialised in the complex gene families of the specific immune response in human and other vertebrates: Immunoglobulins (Ig), T cell Receptors (TcR) and MHC. LIGM-CNRS (F), EBI (UK),ICRF (UK), BPRC (NL) and EUROGENTEC (B) propose to expand IMGT into an information system which will integrate and provide a common access to all protein, polymorphism and structural Ig, TcR and MHC data. By management of the enormous complexity of the immunogenetics data, IMGT will be crucial for functional and comparative genomics of the immune system, biotechnologies, and therapeutic approaches such as vaccines, grafts, and immunotherapies. IMGT will be of immense value for Medicine, Biotechnology and the European Pharmaceutical Industry, and will considerably help to strengthen Europe's role in these areas.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
Rue De La Cardonille 141
34396 Montpellier
France

Participants (4)

CANCER RESEARCH UK
United Kingdom
Address
John Radcliffe Hospital - Institute Of Molecular M
OX3 9DU Oxford/headington
EUROGENTEC SA
Belgium
Address
Rue Bois Saint Jean 14
4102 Ougree
EUROPEAN MOLECULAR BIOLOGY LABORATORY
United Kingdom
Address
Wellcome Trust Genome Campus, Hinxton Hall
CB10 1SD Saffron Walden
FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE
Netherlands
Address
Lange Kleiweg 139
2288 GJ Rijswijk Zh