Objective
Innovative approaches will be used to achieve the main objectives:
a) To identify new factors involved in COX assembly, Tandem Affinity Purification with mass spectrometry and micro arrays technology will be used
b) To study in vivo assembly and turnover of cytochrome c oxidise and determine the role of SURF-1, two- dimensional electrophoresis with metabolic labelling and a novel approach based on the use of fluorescent tags (FRET) will be applied
c) micro arrays will also be used to compare expression levels of the genes in the genome of wild-type, DeltaShy and DeltaShy revertants in different physiological conditions and d) approaches developed in yeast will be tested for diagnostic and information obtained from spontaneous revertants will provide important indications for therapy. These innovative strategies in combination with the high-quality research of the host group will add strong technical background to the applicant and will ensure a successful postdoctoral stay.
Considering the background of the candidate in the mitochondrial field and her motivation, her stay in the lab will be also beneficial and stimulating for the research of the resident lab community.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrophoresis
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1098 SM AMSTERDAM
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.