Knowledge of the extent of linkage disequilibrium (LD) and its variation across the genome is required for the efficient and systematic implementation of mapping functional polymorphisms implicated in common, complex disorders.. The overall goal of this project is to determine extent and variation of LD in the genome of the general population of European populations. DNA from population samples of unrelated individuals will be typed with some 250 micro satellites and SNPs in nine genomic regions and the entire chromosome 22 (C22). The extent of LD will be measured for each region and for C22, and will be compared across populations. The across-population variability of extent of LD will be interpreted by the demographic history of each population. Each genome region will be compared for extent of LD across chromosomes and between populations. Inherent genome, sequence-related characteristics will be used to interpret regional variability. Regions harbouring genes implicated in complex disorders will also be studied. Frequencies phaplotypes extending across each genomic region will be estimated for each population. Computer programs used for data analysis and all DNA types generated in this project will be available to the public at the completion of this project.
Funding SchemeCSC - Cost-sharing contracts
OX3 9DU Oxford/headington
10126 Torino (Turin)