Objective
Knowledge of the extent of linkage disequilibrium (LD) and its variation across the genome is required for the efficient and systematic implementation of mapping functional polymorphisms implicated in common, complex disorders.. The overall goal of this project is to determine extent and variation of LD in the genome of the general population of European populations. DNA from population samples of unrelated individuals will be typed with some 250 micro satellites and SNPs in nine genomic regions and the entire chromosome 22 (C22). The extent of LD will be measured for each region and for C22, and will be compared across populations. The across-population variability of extent of LD will be interpreted by the demographic history of each population. Each genome region will be compared for extent of LD across chromosomes and between populations. Inherent genome, sequence-related characteristics will be used to interpret regional variability. Regions harbouring genes implicated in complex disorders will also be studied. Frequencies phaplotypes extending across each genomic region will be estimated for each population. Computer programs used for data analysis and all DNA types generated in this project will be available to the public at the completion of this project.
Fields of science
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
75010 Paris
France
See on map
Participants (7)
OX3 9DU Oxford/headington
See on map
91057 Evry
See on map
27100 Pavia
See on map
08003 Barcelona
See on map
3012 Bern
See on map
00014 Helsinki
See on map
10126 Torino (Turin)
See on map