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Linkage disequilibrium in European populations

Objective

Knowledge of the extent of linkage disequilibrium (LD) and its variation across the genome is required for the efficient and systematic implementation of mapping functional polymorphisms implicated in common, complex disorders.. The overall goal of this project is to determine extent and variation of LD in the genome of the general population of European populations. DNA from population samples of unrelated individuals will be typed with some 250 micro satellites and SNPs in nine genomic regions and the entire chromosome 22 (C22). The extent of LD will be measured for each region and for C22, and will be compared across populations. The across-population variability of extent of LD will be interpreted by the demographic history of each population. Each genome region will be compared for extent of LD across chromosomes and between populations. Inherent genome, sequence-related characteristics will be used to interpret regional variability. Regions harbouring genes implicated in complex disorders will also be studied. Frequencies phaplotypes extending across each genomic region will be estimated for each population. Computer programs used for data analysis and all DNA types generated in this project will be available to the public at the completion of this project.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FONDATION JEAN DAUSSET - CENTRE D'ETUDE DU POLYMORPHISME HUMAIN
Address
Rue Juliette Dodu 27
75010 Paris
France

Participants (7)

CANCER RESEARCH UK
United Kingdom
Address
John Radcliffe Hospital - Institute Of Molecular M
OX3 9DU Oxford/headington
CONSORTIUM NATIONAL DE RECHERCHE EN GÉNOMIQUE
France
Address
Rue Gaston Cremieux, 2
91057 Evry
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
Address
Via Ferrata 1
27100 Pavia
UNIVERSITAT POMPEU FABRA
Spain
Address
C/ Dr. Aiguader 80
08003 Barcelona
UNIVERSITY OF BERNE
Switzerland
Address
Baltzerstrasse 6
3012 Bern
UNIVERSITY OF HELSINKI
Finland
Address
Kytoesuontie 11
00014 Helsinki
UNIVERSITY OF TORINO
Italy
Address
Via Santena 19
10126 Torino (Turin)