Linkage disequilibrium in European populations

Objective

Knowledge of the extent of linkage disequilibrium (LD) and its variation across the genome is required for the efficient and systematic implementation of mapping functional polymorphisms implicated in common, complex disorders.. The overall goal of this project is to determine extent and variation of LD in the genome of the general population of European populations. DNA from population samples of unrelated individuals will be typed with some 250 micro satellites and SNPs in nine genomic regions and the entire chromosome 22 (C22). The extent of LD will be measured for each region and for C22, and will be compared across populations. The across-population variability of extent of LD will be interpreted by the demographic history of each population. Each genome region will be compared for extent of LD across chromosomes and between populations. Inherent genome, sequence-related characteristics will be used to interpret regional variability. Regions harbouring genes implicated in complex disorders will also be studied. Frequencies phaplotypes extending across each genomic region will be estimated for each population. Computer programs used for data analysis and all DNA types generated in this project will be available to the public at the completion of this project.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-8. - Research into genomes and diseases of genetic origin

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FONDATION JEAN DAUSSET - CENTRE D'ETUDE DU POLYMORPHISME HUMAIN

Address

Rue Juliette Dodu 27
75010 Paris
France

Participants (7)

CANCER RESEARCH UK

United Kingdom

Address

John Radcliffe Hospital - Institute Of Molecular M
OX3 9DU Oxford/headington

CONSORTIUM NATIONAL DE RECHERCHE EN GÉNOMIQUE

France

Address

Rue Gaston Cremieux, 2
91057 Evry

UNIVERSITA DEGLI STUDI DI PAVIA

Italy

Address

Via Ferrata 1
27100 Pavia

UNIVERSITAT POMPEU FABRA

Spain

Address

C/ Dr. Aiguader 80
08003 Barcelona

UNIVERSITY OF BERNE

Switzerland

Address

Baltzerstrasse 6
3012 Bern

UNIVERSITY OF HELSINKI

Finland

Address

Kytoesuontie 11
00014 Helsinki

UNIVERSITY OF TORINO

Italy

Address

Via Santena 19
10126 Torino (Turin)