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Insight inside: signal transducing protein machines revealed by subcellular single molecule spectroscopy and imaging (INSIGHT INSIDE)

Objective

The molecular basis of programmed cell death (PCD ) , a system common to both plants and animals, will be studied to learn more about signal transduction cascades. PCD is a process of cell suicide critical for development and tissue homeostasis of multicellular organisms. It requires sophisticated signal transduction machinery, controlled by an evolutionary conserved program. Understanding PCD is important for drug discovery in human medicine and pathogen resistance in agriculture. Shared features of plant and animal PCD will be used to deduce the primordial components of eukaryotic PCD To increase our understanding in this field, micro spectroscopic techniques will be used because they provide quantitative information on molecular interactions and dynamic events involving signalling molecules (SMD) , they can be used as high throughput methods and combined with other advanced imaging methods.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

WAGENINGEN UNIVERSITY
Address
Binnenhaven 10
6700 ES Wageningen
Netherlands

Participants (2)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
69012 Heidelberg
NOVARTIS FORSCHUNGSINSTITUT GMBH
Austria
Address
Brunner Strasse 59
1235 Wien