Objective
The SH3 domain is the most common protein interaction module in eukaryotic cells. Through their binding to specific proline-rich sequences, SH3 domains play a crucial role in the formation of the multiprotein complexes responsible for signal transduction. The goal of this proposal is to understand the structure and function underlying the SH3-mediated protein network in the model organism Saccharomyces cerevisiae (yeast). To this end we will analyse all 29 yeast SH3 domains in terms of their ligand specificity using phage-displayed combinatorial peptide-and cDNA-libraries, in terms of their structure using X-ray crystallography and NMR, and in terms of their function using whole genome expression profiling. Knowledge of the rules that govern SH3-mediated interactions in yeast will help predicting these interactions in the human proteome and will allow a better understanding of human genetic diseases such as cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- medical and health sciences clinical medicine oncology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
AMSTERDAM
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.