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European rational approach for the genetics of diabetic complications (EURAGEDIC)

Objective

Micro vascular lesions and accelerated arteriosclerosis are the major causes of morbidity and early mortality in diabetic patients. Development of complications is influenced by genetic factors. Identification of the genes in correlation with specific phenotypes will aid a better risk assessment, allow early intervention and the development of new therapeutic approaches. Both excellent clinical and genetic expertise are needed. We propose to combine clinical and genetic data from major European institutions to identify genes involved in diabetic complications. Large patient cohorts will be screened for polymorphisms in candidate genes for association. These studies will be aided through the use of animal models derived for specific phenotypes. The combination of clinic al and human genetic studies on one hand and genetic animal studies on the other will result in a synergistic effect that should allow the dissection of this complex trait.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Boulevard De L'hôpital 91
75634 Paris
France

Participants (5)

HELSINKI UNIVERSITY CENTRAL HOSPITAL
Finland
Address
Kasarmikatu 11-13
00029 Helsinki
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Harwell
OX11 0RD Didcot,harwell,chilton
STENO DIABETES CENTER
Denmark
Address
Niels Steensens Vej 2
2820 Gentoffe
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
Roosevelt Drive
OX3 7BN Oxford/headington
UNIVERSITÉ DE PARIS VII DENIS DIDEROT
France
Address
Rue Henri-huchard 46
75877 Paris