Micro vascular lesions and accelerated arteriosclerosis are the major causes of morbidity and early mortality in diabetic patients. Development of complications is influenced by genetic factors. Identification of the genes in correlation with specific phenotypes will aid a better risk assessment, allow early intervention and the development of new therapeutic approaches. Both excellent clinical and genetic expertise are needed. We propose to combine clinical and genetic data from major European institutions to identify genes involved in diabetic complications. Large patient cohorts will be screened for polymorphisms in candidate genes for association. These studies will be aided through the use of animal models derived for specific phenotypes. The combination of clinic al and human genetic studies on one hand and genetic animal studies on the other will result in a synergistic effect that should allow the dissection of this complex trait.
Funding SchemeCSC - Cost-sharing contracts
OX11 0RD Didcot,harwell,chilton
OX3 7BN Oxford/headington