Objective Micro vascular lesions and accelerated arteriosclerosis are the major causes of morbidity and early mortality in diabetic patients. Development of complications is influenced by genetic factors. Identification of the genes in correlation with specific phenotypes will aid a better risk assessment, allow early intervention and the development of new therapeutic approaches. Both excellent clinical and genetic expertise are needed. We propose to combine clinical and genetic data from major European institutions to identify genes involved in diabetic complications. Large patient cohorts will be screened for polymorphisms in candidate genes for association. These studies will be aided through the use of animal models derived for specific phenotypes. The combination of clinic al and human genetic studies on one hand and genetic animal studies on the other will result in a synergistic effect that should allow the dissection of this complex trait. Fields of science natural sciencesbiological sciencesgeneticssocial sciencessociologydemographymortalitymedical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosismedical and health sciencesclinical medicineendocrinologydiabetes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-8. - Research into genomes and diseases of genetic origin Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Address Boulevard de l'hôpital 91 75634 Paris France See on map EU contribution € 0,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all HELSINKI UNIVERSITY CENTRAL HOSPITAL Finland EU contribution € 0,00 Address Kasarmikatu 11-13 00029 Helsinki See on map MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 0,00 Address Harwell OX11 0RD Didcot,harwell,chilton See on map STENO DIABETES CENTER Denmark EU contribution € 0,00 Address Niels steensens vej 2 2820 Gentoffe See on map THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 0,00 Address Roosevelt drive OX3 7BN Oxford/headington See on map UNIVERSITÉ DE PARIS VII DENIS DIDEROT France EU contribution € 0,00 Address Rue henri-huchard 46 75877 Paris See on map
