Genomic investigation of chronic intestinal inflammation (GENETICS OF IBD)

Objectif

Inflammatory bowel disease (IBD) is a complex, polygenic disorder, which affects mainly young adults. Genetic linkage to susceptibility areas on chromosomes16, 6 and 12 has been confirmed in affected sib pair studies. The life-style of modern industrialised civilisations appears to be a strong trigger for disease manifestation. The applicants use their well-characterised collection of multiplex and monoplex families to identify the genes by systematic association studies utilising polymorphisms of genes in linkage regions. Gene-chip based expression screening (using acDNA array with 38,000 clustered ESTs, which is proprietary to the applicants) will be used to understand the function of known and novel genes in disease pathophysiology. Proteomics approaches are taken to understand the function of differentially expressed genes and for a systematic post expression analysis. Through a complex genotype-phenotype analysis the applicability of molecular findings to the population will be defined. This will result in a validation of molecular abnormalities as novel targets for therapy and/or as screening tools. Extensive statistical and epidemiological analysis will develop a disease model describe the interaction between multiple genetic and life style factors. The proposal will therefore produce exploitable intellectual property resulting in a substantial improvement...

Champ scientifique

• sciences naturelles › sciences biologiques › génétique
• sciences naturelles › sciences biologiques › biochimie › biomolécule › protéines › protéomique
• sciences médicales et de la santé › médecine fondamentale › physiologie › pathophysiologie
• sciences médicales et de la santé › médecine clinique › gastroentérologie › maladie inflammatoire chronique de l’intestin

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Thème(s)

• 1.1.1.-8. - Research into genomes and diseases of genetic origin

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

CHRISTIAN-ALBRECHTS UNIVERSITAET ZU KIEL

Adresse

12,schittenhelmstrasse 12
24105 Kiel
Allemagne

Liens

Participants (5)

DEUTSCHE MORBUS CROHN / COLITIS ULCEROSA VEREINIGUNG E.V.

Allemagne

Adresse

Paracelsusstrasse 15
51375 Leverkusen

Liens

KING'S COLLEGE LONDON

United Kingdom

Adresse

Guy's Hospital, London Bridge, 8th Floor Guy's Tow
SE1 9RT London

Liens

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Allemagne

Adresse

Ihnestrasse 73
14195 Berlin

Liens

UNIVERSITY OF COPENHAGEN

Danemark

Adresse

Blegdamsvej 3
2200 Koepenhagen

Liens

UNIVERSITY OF SOUTHERN DENMARK - UNIVERSITY OF ODENSE

Danemark

Adresse

Campusvej 55
5230 Odense

Liens