Properties and functions of neuronal kcnq/m-type potassium channels mutated in human disease

Objective

The Pharmacological and biophysical properties of members of the KCNQ family of voltage-dependent potassium channels are similar to those of the M-current. Mutations on any of the know four members underlie hereditary disorders, such as epilepsy, cardiac arrhythmia or deafness. Furthermore, several pharmacological studies suggest an important role of this current in cognition processes. Thus, the M-current is a prime target for development of new drugs with potential therapeutically value. This proposal focuses in the physiological role, pharmacological and molecular properties and neuronal distribution of the KCNQ (M) - channel. It aims towards the development of new tools for the study of this channels, to the discovery of new drugs that, by affecting the KCNQ/M M-channels, may be useful in the treatment of some neurological disorders, such as epilepsy and Alzheimer's disease, and to the establishment of a mouse model of deafness.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-9. - Neurosciences

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
Madrid
Spain

Participants (4)

DIVERDRUGS S.L.

Spain

Address

Santa Eulalia 240
08902 Hospitalet Del Llobregat

NEUROSEARCH A/S

Denmark

Address

Pederstrupvej 93
2750 Ballerup

UNIVERSITY OF OSLO

Norway

Address

Problemveien 1
0316 Oslo

Birkbeck College, University of London

United Kingdom

Address

Malet Street, Bloomsbury
WC1E 7HX London