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Properties and functions of neuronal kcnq/m-type potassium channels mutated in human disease

Objective

The Pharmacological and biophysical properties of members of the KCNQ family of voltage-dependent potassium channels are similar to those of the M-current. Mutations on any of the know four members underlie hereditary disorders, such as epilepsy, cardiac arrhythmia or deafness. Furthermore, several pharmacological studies suggest an important role of this current in cognition processes. Thus, the M-current is a prime target for development of new drugs with potential therapeutically value. This proposal focuses in the physiological role, pharmacological and molecular properties and neuronal distribution of the KCNQ (M) - channel. It aims towards the development of new tools for the study of this channels, to the discovery of new drugs that, by affecting the KCNQ/M M-channels, may be useful in the treatment of some neurological disorders, such as epilepsy and Alzheimer's disease, and to the establishment of a mouse model of deafness.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Address
Calle Serrano 117
Madrid
Spain

Participants (4)

DIVERDRUGS S.L.
Spain
Address
Santa Eulalia 240
08902 Hospitalet Del Llobregat
NEUROSEARCH A/S
Denmark
Address
Pederstrupvej 93
2750 Ballerup
UNIVERSITY OF OSLO
Norway
Address
Problemveien 1
0316 Oslo
Birkbeck College, University of London
United Kingdom
Address
Malet Street, Bloomsbury
WC1E 7HX London