Objective
The Pharmacological and biophysical properties of members of the KCNQ family of voltage-dependent potassium channels are similar to those of the M-current. Mutations on any of the know four members underlie hereditary disorders, such as epilepsy, cardiac arrhythmia or deafness. Furthermore, several pharmacological studies suggest an important role of this current in cognition processes. Thus, the M-current is a prime target for development of new drugs with potential therapeutically value. This proposal focuses in the physiological role, pharmacological and molecular properties and neuronal distribution of the KCNQ (M) - channel. It aims towards the development of new tools for the study of this channels, to the discovery of new drugs that, by affecting the KCNQ/M M-channels, may be useful in the treatment of some neurological disorders, such as epilepsy and Alzheimer's disease, and to the establishment of a mouse model of deafness.
Topic(s)
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
Madrid
Spain
Participants (4)
08902 Hospitalet Del Llobregat
2750 Ballerup
0316 Oslo
WC1E 7HX London