While the role of classical neurotransmitters in neuronal communication is comparably well characterised, the actions of neuropeptides remained largely unknown. The objective of this proposal is to provide a complete understanding of the control of neuronal communication by the neuropeptide somatostatin through an elucidation of its antisecretory and antiproliferative actions. The functions of the individual somatostatin receptors will be unravelled in a multidisciplinary approach relying on the development and application of novel experimental tools and strategies. It will become clear how somatostatin signalling affects normal and abnormal brain function. Concepts will emerge regarding novel diagnostics and therapeutic strategies that can be used to treat patients from European populations that suffer from various brain disorders including neurodegenerative diseases, mental and affective disorders and aggressive brain tumours.
Funding SchemeCSC - Cost-sharing contracts