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Somatostatin and its receptors in brain function and dysfunction

Objective

While the role of classical neurotransmitters in neuronal communication is comparably well characterised, the actions of neuropeptides remained largely unknown. The objective of this proposal is to provide a complete understanding of the control of neuronal communication by the neuropeptide somatostatin through an elucidation of its antisecretory and antiproliferative actions. The functions of the individual somatostatin receptors will be unravelled in a multidisciplinary approach relying on the development and application of novel experimental tools and strategies. It will become clear how somatostatin signalling affects normal and abnormal brain function. Concepts will emerge regarding novel diagnostics and therapeutic strategies that can be used to treat patients from European populations that suffer from various brain disorders including neurodegenerative diseases, mental and affective disorders and aggressive brain tumours.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

GERMAN INSTITUTE OF HUMAN NUTRITION
Address
Arthur-scheunert-allee 114-116
14558 Bergholz-rehbr Cke
Germany

Participants (9)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
INSTITUTO NAZIONALE PER LA RICERCA SUL CANCRO
Italy
Address
Largo Rosanna Benzi 10
16132 Genova
MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH
Italy
Address
Via Eritrea 62
20157 Milano
NOVARTIS PHARMA AG
Switzerland
Address
Lichtstrasse 35
Basel
OTTO VON GUERICKE UNIVERSITAET MAGDEBURG
Germany
Address
Leipzigstrasse 44
39120 Magdeburg
THE BABRAHAM INSTITUTE
United Kingdom
Address
Babraham Hall
Cambridge
UNIVERSITY OF CRETE
Greece
Address
Ampelokipoi
71110 Iraklion
UNIVERSITY OF HAMBURG
Germany
Address
Süderfeldstrasse 24
22529 Hamburg
Università degli Studi di Pisa
Italy
Address
Lungarno Pacinotti 45
56100 Pisa