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Enhanced multiphoton excitation methods for neuroscience

Objective

Neuroscience, and biomedical research in particular requires methods for observing small, faint structures deep within living tissue. Confocal laser scanning microscopy has provided important advances and its successor technology multiphoton excitation microscopy offers even greater benefits. To help realise these benefits, the collaborators on this project will develop new and more efficient fem to second lasers, scanning and detecting devices, 2-photon absorbing probes and fluroscent lifetime imaging methods. these devices will be exploited to investigate vesicular excytosis and mechanisms responsible for persistent changes in synaptic strength in the mammilian central nervous system.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Medical Research Council (MRC)
Address
20 Park Crescent
W1N 4AL London
United Kingdom

Participants (7)

BEN GURION UNIVERSITY OF THE NEGEV
Israel
Address
653
84105 Beer Sheva
BIO-RAD MICROSCIENCE LTD.
United Kingdom
Address
Bio-rad Microscience Ltd, Bio-rad House, Maylands
HP2 7TD Hemel Hempsteap
SOREQ NUCLEAR RESEARCH CENTER
Israel
Address
Nahal Soreq -
Yavne
T.I.L.L PHOTONICS GMBH
Germany
Address
4A,lena Christ Str. 44
82152 Planegg
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Address
Via Olgettina, 58
20132 Milano
UNIVERSITY OF STRATHCLYDE
United Kingdom
Address
16 Richmond Street
Glasgow
WISE & MUNRO LEARNING RESEARCH
Netherlands
Address
8,Azaleastraat 85
2565 CD Den Haag