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Enhancement of clinical value of functional imaging through automated removal of partial volume effect

Objective

In medicine, images of the structure (e.g. MRI) and function (e.g. Nuclear Medicine techniques) of the brain are used. Functional images are hampered by low resolution, resulting in contamination of the signal of each region from the surrounding structures (Partial Volume Effect -PVE), limiting their applications, especially when atrophy is present (e.g. in Alzheimer's Disease). Functional images can be corrected knowing the shape and size of corresponding brain structures as assessed by structural imaging. This projects aims at:
1) setting upon automated method for correction of functional low-resolution brain imaging;
2)validating it using specifically designed anthropomorphic phantoms;
3) applying it on pre-existing normal volunteers and patients studies. This software, validated by a team of European Centres, will set a standard for FVE correction, providing a tool for excellence of European research and of health care in brain disease.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NATIONAL RESEARCH COUNCIL OF ITALY
Address
Piazzale Aldo Moro 7
00185 Roma
Italy

Participants (6)

COPENHAGEN UNIVERSITY HOSPITAL
Denmark
Address
Blegdamsvej 9
2100 Koepenhagen
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Boulevard Henri Becquerel Adr 7 - Nord-pas-de-cal
14021 Caen
KAROLINSKA INSTITUTE
Sweden
Address
Novum, Kfc Plan 4
141 86 Stockholm
RASNA
Italy
Address
Via Panciatichi, 26/3
50127 Firenze
UNIVERSITY OF DEBRECEN
Hungary
Address
Nagyerdei Krt. 98
4012 Debrecen
UNIVERSITY OF KENT AT CANTERBURY
United Kingdom
Address
The University Of Kent At Canterbury
CT2 7NZ Canterbury