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Nuclear hormone receptor co-regulators

Objective

Steroid and thyroid hormones influence brain structure and function from early development through to ageing. Their actions are mediated by nuclear hormone receptors (NR) that regulate gene transcription via association with proteins that modulate their transactivation potential (nuclear receptor co-regulators;NRC) . Little is known on NRC in the brain despite their potential importance for determining NR signalling efficacy during and specificity. This project seeks to identify novel, and characterise the significance of select NRC in brain development and function using state-of-the-art methods of molecular and cell biology. The project will contribute to cell and molecular neuroscience, and will serve in the development of more effective drugs or gene therapies for brain disorders.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
Rue Cuvier 7
75231 Paris
France

Participants (3)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES
Hungary
Address
Szigony U. 43
1083 Budapest
JENAPHARM GMBH & CO
Germany
Address
Otto-schott-str. 15
07745 Jena