Steroid and thyroid hormones influence brain structure and function from early development through to ageing. Their actions are mediated by nuclear hormone receptors (NR) that regulate gene transcription via association with proteins that modulate their transactivation potential (nuclear receptor co-regulators;NRC) . Little is known on NRC in the brain despite their potential importance for determining NR signalling efficacy during and specificity. This project seeks to identify novel, and characterise the significance of select NRC in brain development and function using state-of-the-art methods of molecular and cell biology. The project will contribute to cell and molecular neuroscience, and will serve in the development of more effective drugs or gene therapies for brain disorders.
Funding SchemeCSC - Cost-sharing contracts
67404 Illkirch Graffenstaden