Objective The overall aim of our proposal is to generate cells or therapeutic compounds that will repair the lesions of the common neurological disorder Multiple Sclerosis. To achieve this aim we will pursue a series of objectives: (1) Generate neural precursor cells with enhanced migration properties that can reach and repair sites of demyelination in the central nervous system (CNS) following transplantation in animal models for the disease; (2) Develop techniques to manipulate neural precursor migration in a transient manner if differentiation of these exogenous cells is hampered in some way ;(3) Characterize the cell surface signalling that stimulate precursor cell migration in order to design compounds enhancing the recruitment of endogenous myelin-forming cells at sites of demyelination Our strategy will be based on manipulating molecules known to be permissive for migration during development of the nervous system such as the polysialylated form of NCAM and chemokines or important for signalling during migration such as integrins. Our final assay will be the restoration of fast nerve conduction in the remyelinated fibbers. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesclinical medicinetransplantation Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-9. - Neurosciences Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUT PASTEUR Address Rue du docteur roux 25 75724 Paris France See on map EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution € 0,00 Address 31,campus de luminy 13288 Marseille See on map HELLENIC PASTEUR INSTITUTE Greece EU contribution € 0,00 Address See on map RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN Germany EU contribution € 0,00 Address Sigmund-freud-strasse 25 53105 Bonn See on map SERONO INTERNATIONAL S.A. Switzerland EU contribution € 0,00 Address Chemin des aulx 14 1228 Plan-les-ouates See on map THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 0,00 Address Robinson way, forvie site CB2 2PY Cambridge See on map UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II France EU contribution € 0,00 Address Campus de luminy 13288 Marseille See on map
