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Neurodevelopmental disorders in premature infants caused by thyroid hormone insufficiency - molecular basis for diagnosis and therapy

Objective

Transient hypothyroxinaemia in prefer infants are associated with laterneurodevelopmental deficits in motor and cognitive function. The overarching goal of our research programme is to determine the molecular basis of transient pothyroxinaemia of prefer infants and to use this information to drive the development of novel preventive and/or therapeutic strategies for these widespread and potentially debilitating handicaps of brain function. Here we have assembled an international and multidisciplinary research consortium, which is in a unique position to achieve this goal, with a combination of clinical, scientific, and manufacturing expertise. We plan to study at the molecular level the major pathways of iodothyronine metabolism and iodine supply in early human life and in experimental models, and then translate this information into new products for detecting, preventing and correcting transient thyroid dysfunction of prematurely.

Coordinator

UNIVERSITY OF DUNDEE
Address
Ninewells Hospital & Medical School
DD1 9SY Dundee
United Kingdom

Participants (5)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Arturo Duperier 4
28029 Madrid
ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
Address
Dr. Molewaterplein 50
3015 GE Rotterdam
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Naamsestraat 61
3000 Louvain / Leuven
NUMICO RESEARCH B.V.
Netherlands
Address
Bosrandweg 20
6700 CA Wageningen
QUANTASE LTD.
United Kingdom
Address
3, Riverview Business Park, Friarton Road
PH2 8DF Perth