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Gene search towards the identification of novel therapeutic strategies against brain ischemia

Objective

Stroke and other manifestations of brain schema are common and devastating disorders which dramatically deteriorate the patients quality of life and which in the EU produce annual costs of approximately 35 billions Euro. At the present no efficient therapy is available but there is increasing evidence that the outcome of alchemic injury is regulated by intrinsic genomic responses. To search for such genes, clinically relevant experimental brain schema models will be produced. Brain regions with reversible and irreversible injury will be identified and high throughput gene expression profiling will be carried out using Digital Expression Pattern Display *DEPD* and automated DNA chip technology. Outcome-specific genes will be identified and tested for path physiological relevance. Based on this information novel treatment strategies will be designed and evaluated forcherapeutical efficacy.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Address
Gleueler Strasse 50
50931 Köln
Germany

Participants (6)

BIOFRONTERA PHARMACEUTICALS GMBH
Germany
Address
Hemmelrather Weg 201
51377 Leverkusen
ECOLE SUPERIEURE DE PHYSIQUE ET CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
France
Address
Rue Vauquelin 10
Paris
KAROLINSKA INSTITUTE
Sweden
Address
Von Eulers Vag 3
171 77 Stockholm
MEDICAL RESEARCH CENTRE - POLISH ACADEMY OF SCIENCES
Poland
Address
Pawinskiego 5
02 106 Warszawa
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
Address
3,Via G. Colombo 3
35121 Padova
UNIVERSITY OF BRADFORD
United Kingdom
Address
Richmond Road
BD7 1DP Bradford