Gene search towards the identification of novel therapeutic strategies against brain ischemia

Objective

Stroke and other manifestations of brain schema are common and devastating disorders which dramatically deteriorate the patients quality of life and which in the EU produce annual costs of approximately 35 billions Euro. At the present no efficient therapy is available but there is increasing evidence that the outcome of alchemic injury is regulated by intrinsic genomic responses. To search for such genes, clinically relevant experimental brain schema models will be produced. Brain regions with reversible and irreversible injury will be identified and high throughput gene expression profiling will be carried out using Digital Expression Pattern Display *DEPD* and automated DNA chip technology. Outcome-specific genes will be identified and tested for path physiological relevance. Based on this information novel treatment strategies will be designed and evaluated forcherapeutical efficacy.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-9. - Neurosciences

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Address

Gleueler Strasse 50
50931 Köln
Germany

Participants (6)

BIOFRONTERA PHARMACEUTICALS GMBH

Germany

Address

Hemmelrather Weg 201
51377 Leverkusen

ECOLE SUPERIEURE DE PHYSIQUE ET CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

France

Address

Rue Vauquelin 10
Paris

KAROLINSKA INSTITUTE

Sweden

Address

Von Eulers Vag 3
171 77 Stockholm

MEDICAL RESEARCH CENTRE - POLISH ACADEMY OF SCIENCES

Poland

Address

Pawinskiego 5
02 106 Warszawa

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

Address

3,Via G. Colombo 3
35121 Padova

UNIVERSITY OF BRADFORD

United Kingdom

Address

Richmond Road
BD7 1DP Bradford