Objective
We propose to analyse the synaptic integration in the mistral cell dendrites during synaptic activation by electrophysiological recordings and simultaneous calcium imaging at the single cell level. The long-term goal is to combine cellular and network experiments in the analysis of the mistral cell dendrite function during network activity, using the turtle olfactory bulb at physiological temperature. The analysis will be facilitated by the ability to record from the distal dendrites electrophysiological events, which may occur distally, while only small responses are observed in recordings from the cell body. Recordings from the dendrites will be combined with stimulation of the olfactory nerve (ON). This allows a precise analysis of the ON EPSP, including the response as function of presynaptic firing frequency, and gives estimation of the number of presynaptic axons needed to evoke local vs. somatic spikes. ON stimulation or mistral cell dendrite spiking is followed by local inhibitory synaptic activity in the tuft. Minimal, focal ON activation and periglomerular stimulation will evoke Pips in the mistral cells, which can be compared with the Pips due to dendro-dendritic feedback following postsynaptic spiking in the mistral cell recorded from. After the electrophysiological experiments, the distribution of the dendrite calcium concentration during ON activation will be analysed by simultaneous whole cell recording and calcium imaging. The mistral cell de
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2200 KOEPENHAGEN
Denmark
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