Objective
The laboratories of K Fuse (Sweden), L Agnate (Italy), R Franco (Spain), M Bader (Germany), J Schell-Kruger (Neurosearch, Denmark), A Rankin (Estonia) and S.Schiffmann (Belgium) regroup for the project. This consortium has recently demonstrated that adenosine (Ado) /dopamine (DA) receptor (R) heteromerization playa important role in striate neuronal functions. These results open new perspectives for the knowledge and therapy of neurological diseases. The project aims towards
1) Understanding the structural and molecular basis of Ado/DA R heteromerization;
2) Understanding the role of Ado/DA heteromers in cell function and strictly regulated functions, also involving the study of knock-in mice with mutated A2A and D2 R lacking the ability to heteromerize;
3) Preclinical development of novel A2A and A1 compounds target in the A2A/D2 and A1 /D1 heteromers, respectively, for treatment of Parkinson's disease (PD).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.