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Heteromerization of adenosine and dopamine receptor subtypes. relevance for neuronal integration in normal and pathological states (RECEPTOR HETERODIMER)

Objective

The laboratories of K Fuse (Sweden), L Agnate (Italy), R Franco (Spain), M Bader (Germany), J Schell-Kruger (Neurosearch, Denmark), A Rankin (Estonia) and S.Schiffmann (Belgium) regroup for the project. This consortium has recently demonstrated that adenosine (Ado) /dopamine (DA) receptor (R) heteromerization playa important role in striate neuronal functions. These results open new perspectives for the knowledge and therapy of neurological diseases. The project aims towards
1) Understanding the structural and molecular basis of Ado/DA R heteromerization;
2) Understanding the role of Ado/DA heteromers in cell function and strictly regulated functions, also involving the study of knock-in mice with mutated A2A and D2 R lacking the ability to heteromerize;
3) Preclinical development of novel A2A and A1 compounds target in the A2A/D2 and A1 /D1 heteromers, respectively, for treatment of Parkinson's disease (PD).

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KAROLINSKA INSTITUTE
Address
Berzelius Väg 3
171 77 Stockholm
Sweden

Participants (8)

MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE
Germany
Address
Robert-roessle-strasse 10
13092 Berlin
NEUROSEARCH A/S
Denmark
Address
Pederstrupvej 93
2750 Ballerup
UNIVERSITAT DE BARCELONA
Spain
Address
Avda Diagonal 645
08028 Barcelona
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
Ulb Cp610, Route De Lennik 808
1070 Bruxelles
UNIVERSITY OF MODENA AND REGGIO EMILIA
Italy
Address
Via G.campi 287
41100 Modena
UNIVERSITY OF TARTU
Estonia
Address
Jakobi Str. 2
51014 Tartu
UNIVERSITÀ DEGLI STUDI DI FERRARA
Italy
Address
Via Fossato Di Mortara, 17-19
44100 Ferrara
UPPSALA UNIVERSITY
Sweden
Address
Husargatan
75123 Uppsala