Objective Synapses are key elements for neuronal communication in the brain. Many synaptic proteins are targets for neuropharmaceuticals as well as neurotoxins and street drugs. Synaptic dysfunction is associated with various neurological disorders. The pivotal objectives of this study are to gain precise insight into processes of synaptic assembly and function, to understand path mechanisms underlying synaptic dysfunction and to discover novel targets for neuropharmaceuticals. The skills of the partners in molecular biology, genetics (including advanced trans-genie technologies in mouse and fly), bio informatics, biochemistry, electro-physiology, cell biology and functional anatomy will be combined to: study mechanisms of synapse assembly, identify genes involved in acquisition of synaptic competence (i.e. the ability to form synapses), analyse molecular mechanisms of transmitter release, and find and validate new potential drug targets. Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineanatomy and morphologynatural sciencesbiological sciencescell biologymedical and health sciencesbasic medicineneurologynatural sciencesbiological sciencesmolecular biology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-9. - Neurosciences Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE EU contribution No data Address Brenneckestrasse 6 39118 MAGDEBURG Germany See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution No data Address Av. Doctor Arce 37 28002 MADRID See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue d'Ulm 46 75230 PARIS See on map Total cost No data PARADIGM THERAPEUTICS LIMITED United Kingdom EU contribution No data Address Downing Street CB1 4BZ CAMBRIDGE See on map Total cost No data UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE Spain EU contribution No data Address Avenida del Ferrocarril s/n 03202 ELX - ALICANTE See on map Total cost No data UNIVERSITY OF MANCHESTER United Kingdom EU contribution No data Address Oxford Road MANCHESTER See on map Links Website Opens in new window Total cost No data University of Cambridge United Kingdom EU contribution No data Address Downing Street CB2 3EH Cambridge See on map Total cost No data
