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Assembly, maintenance and novel potential drug targets of the synapse (SYNAPTOGENET)

Objective

Synapses are key elements for neuronal communication in the brain. Many synaptic proteins are targets for neuropharmaceuticals as well as neurotoxins and street drugs. Synaptic dysfunction is associated with various neurological disorders. The pivotal objectives of this study are to gain precise insight into processes of synaptic assembly and function, to understand path mechanisms underlying synaptic dysfunction and to discover novel targets for neuropharmaceuticals. The skills of the partners in molecular biology, genetics (including advanced trans-genie technologies in mouse and fly), bio informatics, biochemistry, electro-physiology, cell biology and functional anatomy will be combined to: study mechanisms of synapse assembly, identify genes involved in acquisition of synaptic competence (i.e. the ability to form synapses), analyse molecular mechanisms of transmitter release, and find and validate new potential drug targets.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE
Address
Brenneckestrasse 6
39118 Magdeburg
Germany

Participants (6)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Av. Doctor Arce 37
28002 Madrid
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue D'ulm 46
75230 Paris
PARADIGM THERAPEUTICS LIMITED
United Kingdom
Address
Downing Street
CB1 4BZ Cambridge
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
Address
Avenida Del Ferrocarril S/n
03202 Elx - Alicante
UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
University of Cambridge
United Kingdom
Address
Downing Street
CB2 3EH Cambridge